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Issue 16, 1988
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γ-Lactam formation from tripeptides with isopenicillin N synthase

Abstract

Incubation of isopenicillin N synthase (IPNS) with analogues of the natural substrate [(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine (2) in which the cysteinyl residue was replaced by homocysteine gave epimeric 5-hydroxy γ-lactams (10), with no evidence for the formation of bicyclic products.

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Article information


J. Chem. Soc., Chem. Commun., 1988, 1128-1130
Article type
Paper

γ-Lactam formation from tripeptides with isopenicillin N synthase

J. E. Baldwin, W. J. Norris, R. T. Freeman, M. Bradley, R. M. Adlington, S. Long-Fox and C. J. Schofield, J. Chem. Soc., Chem. Commun., 1988, 1128
DOI: 10.1039/C39880001128

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