Preparation and properties of trimethylammonium group-containing analogues of [D-Ala2, Leu5]enkephalin and gramicidin S
Abstract
Quaternization of primary amino groups of derivatives of [D-Ala2, Leu5]enkephalin and gramicidin S with Mel–KHCO3 in MeOH afforded new biologically active analogues possessing trimethylammonium group(s).