A new synthesis of optically active β-hydroxy carboxylic acids has been developed which is based on the (modest) diastereoselective addition of the chiral nitrile oxide (4) to 1,2-disubstituted alkenes.
A. P. Kozikowski, Y. Kitagawa and J. P. Springer, J. Chem. Soc., Chem. Commun., 1983, 1460 DOI: 10.1039/C39830001460
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