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Issue 2, 1983
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Mechanism of pyridoxal phosphate-dependent enzymatic amino-acid racemization

Abstract

Conversion of L-[α-2H]alanine in H2O and unlabelled L-alanine in 2H2O into D-alanine, under nearly single-turnover conditions, with tyrosine phenol-lyase and with amino-acid racemase from Pseudomonas striata showed significant internal return of the α-hydrogen; the results support a single base mechanism for the racemization reactions catalysed by these two pyridoxal phosphate enzymes but with a third enzyme, alanine racemase from E. coli, the results were inconclusive, showing no detectable α-hydrogen return.

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Article information


J. Chem. Soc., Chem. Commun., 1983, 82-83
Article type
Paper

Mechanism of pyridoxal phosphate-dependent enzymatic amino-acid racemization

S. Shen, H. G. Floss, H. Kumagai, H. Yamada, N. E. K. Soda, S. A. Wasserman and C. Walsh, J. Chem. Soc., Chem. Commun., 1983, 82 DOI: 10.1039/C39830000082

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