The biotransformation of a drug may result in a diversity of metabolites with widely differing physico-chemical properties. With the aid of suitable examples the applicability of adsorption, partition and paired ion high-performance liquid chromatography to the measurement of drugs and their metabolites is discussed in relation to their lipophilicity and polarity.
G. G. Skellern, Analyst, 1981, 106, 1071 DOI: 10.1039/AN9810601071
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