1-(1-Adamantyl)-1-methylethoxycarbonyl (Adpoc) fluoride, a useful reagent for synthesis of a new class of protected amino-acids with advantageous properties for peptide synthesis
Abstract
Amino protection of amino-acids with the new, acid-labile Adpoc group is achieved by acylation with Adpoc fluoride, a very reactive and stable compound; the reagent allows the introduction of the Adpoc group under mild conditions and in high yields.