The phenylacetamido-side-chain of penicillin and desacetoxy-cephalosporin esters was exchanged by a trifluoroacetamido-group in high yield on reaction with trifluoroacetic anhydride and subsequently 1,5-diazabicyclo[4.3.0]-non-5-ene. Methyl 7-trifluoroacetamidodesacetoxycephalosporanate gave the acetamido-analogue with acetyl chloride and the Δ2-amino-acid on alkaline hydrolysis.
A. G. M. Barrett, J. Chem. Soc., Perkin Trans. 1, 1979, 1629 DOI: 10.1039/P19790001629
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