Electrophilic amidoalkylation of benzene and dimethyl malonate with cyclic N-formyl-2-methoxyamines
Abstract
Cyclic N-formyl-2-methoxyamines (derived from pyrrolidine, piperidine, and hexahydroazepine) amido-alkylate benzene and dimethyl malonate using AlCl3 as a catalyst in 44–55 and 70–73% yields respectively.