Seven-membered ring annelation via Cope rearrangement of β-(2-vincyclopropyl)-αβ-unsaturated ketones: a new synthesis of (±)-β-himachalene
Abstract
A total synthesis of (±)-β-himachalene (1), involving the Cope rearrangement of the substituted β-(2-vinylcyclopropyl) enone (9) as a key step, is described.