Studies in terpenoid biosynthesis. Part XVII. Biosynthesis of the sesquiterpenoids cyclonerodiol and cyclonerotriol
Abstract
The labelling patterns of cyclonerodiol and cyclonerotriol, biosynthesized from [4 5-13C2]mevalonic acid, have been determined. The incorporations of [23-H2;2-14C]-, and [(4R)-4-3H;2-14C]-, and [5-3H2;2-14C]-mevalonic acid into farnesyl pyrophosphate and cyclonerodiol are described. Nerolidol was not incorporated into these fungal metabolites.