Issue 13, 1976

A new benzyl ester resin with increased stability during Nα-t-butyloxycarbonyl deblocking in solid-phase peptide synthesis

Abstract

A p-carbamoylmethylbenzyl ester linkage between Boc-phenylalanine and polystyrene resin has been prepared and shown to possess great stability toward trifluoroacetic acid and good reactivity toward liquid HF as demonstrated by the synthesis of a model peptide.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1976, 504-505

A new benzyl ester resin with increased stability during Nα-t-butyloxycarbonyl deblocking in solid-phase peptide synthesis

J. Blake and C. H. Li, J. Chem. Soc., Chem. Commun., 1976, 504 DOI: 10.1039/C39760000504

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