Spectroscopic and degradative methods with 1,2-13C2-acetate and 2-14C-4R-3H-mevalonate precursors show that aphidicolin arises from initial chair-boat cyclization of the diterpene chain followed by successive H-shift, cyclization, and rearrangement steps.
M. R. Adams and J. D. Bu'Lock, J. Chem. Soc., Chem. Commun., 1975, 389 DOI: 10.1039/C39750000389
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