Purine studies. Part XII. Derivatives resulting from acylation and subsequent ethylation of 4,5-diamino-6-methyl-2-methylthiopyrimidine

Abstract

The structures of the various products arising from acetylation of 4,5-diamino-6-methyl-2-methylthiopyrimidine have been identified by means of ¹H n.m.r. and by their conversion into known compounds. Ethylation of the acetylated derivatives does not take place at the same exocyclic nitrogen atom in every case; the site of reaction is a reflection of the change in relative basicity of the 4- and 5-amino-groups which results from their acetylation.