Reaction of dimethylvinylidene with γγ-dimethylallyl methyl sulphide. Synthesis of 2,5,5-trimethylhepta-2,6-dien-4-one (artemisia ketone)
Abstract
The [2,3] sigmatropic rearrangement of the sulphonium ylide derived from the title reaction, followed by hydrolysis of the allenic thioether product affords artemisia ketone (6).