The water-soluble steroid (I) acts as a catalyst for the hydrolysis of active esters, with a definite specificity for esters of 3-arylpropionic acids, the ester of 3-(3-phenanthryl)propionic acid being the most rapidly hydrolysed substrate found to date; it is concluded that imidazole-catalysed hydrolysis of the esters is facilitated by hydrophobic interactions between substrate and catalyst.
J. P. Guthrie and Y. Ueda, J. Chem. Soc., Chem. Commun., 1973, 898 DOI: 10.1039/C39730000898
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