The synthesis is described of a series of (3-substituted 4-pyridyl)pyruvic acids by condensation of the corresponding 4-methylpyridines with diethyl oxalate followed by hydrolysis. Ethyl 3-(3-cyano-4-pyridyl)pyruvate and 3-(3-nitro-4-pyridyl)pyruvic acid are inhibitors of lactate dehydrogenase in vitro.
D. J. Sheffield and K. R. H. Wooldridge, J. Chem. Soc., Perkin Trans. 1, 1972, 2506 DOI: 10.1039/P19720002506
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