Total syntheses of (–)-O-methylandrocymbine, (–)-kreysigine, and alkaloid CC-10 methyl ether
Abstract
(–)-O-Methylandrocymbine (1) was obtained from (–)-1-(2-bromo-3,4,5-trimethoxyphenethyl)-1,2,3,4-tetrahydro-7-hydroxy-6-methoxy-2-methylisoquinoline (13a) by irradiation. The corresponding (+)-phenolic bromoisoquinoline (13b) gave alkaloid CC-10 methyl ether [(+)-O-methylandrocymbine](3) and (–)-kreysigine (6).