A stereospecific exchange reaction at the β-CH2 of phenylalanine, competing with gliotoxin biosynthesis
Abstract
Gliotoxin biosynthesis in Trichoderma viride proceeds with the retention of both hydrogens of the CH2 group of phenylalanine, but in competition with a stereospecific reaction of the phenylalanine in which the 3′-S-hydrogen is exchanged.