Stereochemistry of the acetalization of hexafluoroacetone with a bromohydrin
Abstract
Acetalization of hexafluoroacetone with threo- and erythro-5-bromo-octan-4-ol has been shown to be highly trans-specific by 19F n.m.r., providing a method for establishing the stereochemistry of bromohydrins and their precursors when they are reacted stereospecifically.