Synthesis of 1H-benzo[de]cinnolines (1H-1,2-diazaphenalenes)
Abstract
8-Hydroxy-1-naphthyl ketones condense with hydrazine to give 1H-benzo[de]cinnolines(1H-1,2-diazaphenalenes), whose conjugate bases are methylated at position 1. The oxime of 8-acetyl-1-naphthol cyclises to 3-methylnaphtho[1,8-de]-1,2-oxazine.