The 2-(p-nitrophenylthio)ethyl group for carboxy-group protection in peptide synthesis
Abstract
The 2-(p-nitrophenylthio)ethyl group may be used, as an alternative to the 2-methylthioethyl group, for carboxyl-group protection in peptide synthesis and has certain advantages. The group is selectively removed after conversion into the corresponding sulphone by treatment with alkali (pH 10–10·5 at room temperature).