Nucleosides. Part VII. The reaction of metal salts of thymine and uracil with tetra-acetyl-α-glucopyranosyl bromide

Abstract

The formation of glucosides from the reaction of the silver salts of uracil and thymine with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide has been studied. Both thymine and uracil yield the acetylated N(3)-glucoside and N(3)O(6)-bisglucoside, and the O(2)O(6)-bisglucoside. In addition, uracil yields the acetylated N(1)-glucoside and N(1)N(3)-bisglucoside. Comparison with the products obtained from dithyminylmercury and monothyminylmercury is made.