An improved method for the synthesis of nicotinamide ribosides is described. Nicotinamide and 4-methylnicotinamide condense with 3,5-di-O-benzoly-D-ribofuranosyl chloride to give the dibenzoylribofuranosides in good yield. The ribosides obtained by mild hydrolysis contain predominantly the β-anomer.
M. Jarman and W. C. J. Ross, J. Chem. Soc. C, 1969, 199 DOI: 10.1039/J39690000199
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