Alkyl–oxygen heterolyses in 4-arylpiperidin-4-ols and related esters. Part III. Some 4-alkoxy-4-arylpiperdines
Abstract
The acid-catalysed etherification of some 4-arylpiperidin-4-ols (and esters) is reported and the greater reactivity of cis, compared with trans(3-Me,4-Ph).3-methyl analogues demonstrated. 4-Alkoxypiperidine syntheses of the Williamson type and by the ring opening of 4-piperidone ethylene ketals with phenylmagnesium bromide are also described.