Amide as a protecting group in phosphate ester synthesis. Part I. The acid hydrolysis of some phosphoramidic diesters
Abstract
The acid hydrolysis of a series of N-substituted diphenyl and di-n-butyl phosphoramidates has been studied. The N-methyl compounds were the most readily hydrolysed; in refluxing 25% aqueous formic acid, specific cleavage of the P–N bond was complete in a few minutes.