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Correction: Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation

Michael J. Bonda and Craig M. Crews*abc
aDepartment of Pharmacology, Yale University, New Haven, CT 06511, USA. E-mail: craig.crews@yale.edu
bDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
cDepartment of Chemistry, Yale University, New Haven, CT 06511, USA

Received 11th December 2025 , Accepted 11th December 2025

First published on 5th January 2026


Abstract

Correction for ‘Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation’ by Michael J. Bond et al., RSC Chem. Biol., 2021, 2, 725–742, https://doi.org/10.1039/D1CB00011J.


The authors regret that an incorrect version of Fig. 4 was included in the original article which labelled Bordoxalone as an Irreversible covalent E3 ligase recruiting element (E3RE), when Bordoxalone should have been labelled as a Reversible covalent E3RE. This was stated correctly in the main text. The correct version of Fig. 4 is presented below.
image file: d5cb90053k-f4.tif
Fig. 4 Chemical structures of E3 ligase recruiting elements (E3REs) used in TPD.

The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


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