Open Access Article
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Retraction: Tetracycline-controllable artificial microRNA-HOTAIR + EZH2 suppressed the progression of bladder cancer cells
Yincong
Chen
a,
Haibiao
Xie
ab,
Yifan
Zou
ab,
Xiulan
Lai
ac,
Lian
Ma
ac,
Yuchen
Liu
*b and
Jianfa
Li
*ab
aShantou University Medical College, Shantou 515041, Guangdong Province, China. E-mail: liuyuchenmdcg@163.com; lijianfayouxiang@163.com
bKey Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518039, Guangdong Province, China
cDepartment of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China
First published on 22nd April 2025
Abstract
Retraction of ‘Tetracycline-controllable artificial microRNA-HOTAIR + EZH2 suppressed the progression of bladder cancer cells’ by Yincong Chen et al., Mol. BioSyst., 2017, 13, 1597–1607, https://doi.org/10.1039/C7MB00202E.
The Royal Society of Chemistry hereby wholly retracts this Molecular BioSystems article due to concerns with the reliability of the data.
In Fig. 6c there is overlap in the panels labelled ‘T24/miR-NC + dox’ and ‘T24/miR-NC - dox’. In Fig. 8a there is overlap in the flow cytometry panels labelled ‘5637/miR-NC + dox’ and ‘5637/miR-NC - dox’. In Fig. 8a there is overlap in the flow cytometry panel ‘5637/miR-HOTAIR + EZH2’ and a panel labelled ‘5637 pcDNA3.1-ABHD11-AS1’ found in Fig. 7c of another publication by different authors.1 In Fig. 9d, there is overlap in the left panel labelled ‘miR-HOTAIR + EZH2 + dox’ and the left panel labelled ‘mIR-NC + dox’.
The authors claim that these mistakes are due to a misplacement of images and provided replacement data for consideration. However, the author's response did not satisfactorily address the concerns, and the replacement figures do not fully support the text.
Given the significance of the concerns about the validity of the data, the findings presented in this paper are no longer reliable.
The authors have been informed but have not responded to any correspondence regarding the retraction.
Signed: Katie Lim, Executive Editor
Date: 4th April 2025
References
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