Werner Theodor
Jauslin
a,
Matthias
Schild
a,
Thorsten
Schaefer
b,
Chiara
Borsari
b,
Clara
Orbegozo
b,
Lukas
Bissegger
b,
Saule
Zhanybekova
a,
Danilo
Ritz
c,
Alexander
Schmidt
c,
Matthias
Wymann
*b and
Dennis
Gillingham
*a
aDepartment of Chemistry, University of Basel, 4056 Basel, Switzerland. E-mail: dennis.gillingham@unibas.ch
bDepartment of Biomedicine, University of Basel, 4031 Basel, Switzerland. E-mail: matthias.wymann@unibas.ch
cProteomics Core Facility, Biozentrum University of Basel, 4056 Basel, Switzerland
First published on 15th January 2024
Correction for ‘A high affinity pan-PI3K binding module supports selective targeted protein degradation of PI3Kα’ by Werner Theodor Jauslin et al., Chem. Sci., 2024, https://doi.org/10.1039/D3SC04629J.
W. J., M. S., M. W., and D. G. collaborated in all aspects of project design and conception. W. J. performed chemical synthesis and initial cellular testing of all molecules, including mechanistic experiments. W. J. and M. S. designed the proteomics experiments and performed the initial experimental setup in collaboration with D. R. and A. S., D. R. and M. S. performed the global and targeted proteomics in collaboration under the supervision of D. G. and A. S. Cellular engineering was done by S. Z. and testing of engineered cells was done by W. J. Measurement of binding data and In-Cell Western assays were performed by L. B. and C. O. under the supervision of M. W. C. B. helped with the initial designs of PROTAC structures and contributed to the chemical synthesis of initial VHL targeting molecules and T. S. performed the cellular studies examining degradation levels across several mutated cell lines. The first draft of the manuscript was prepared by W. J., M. S., M. W. and D. G. Refinement was done with contributions from all authors.
The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
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