Open Access Article
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Expression of Concern: Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway
Zhi-Yong
Tian
ab,
Song-Qiang
Xie
c,
Zi-Hou
Mei
d,
Jin
Zhao
a,
Wen-Yuan
Gao
*b and
Chao-Jie
Wang
*a
aKey Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, 475001, China. E-mail: wcjsxq@henu.edu.cn; Fax: +86-378-2864665
bSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, China. E-mail: pharmgao@tju.edu.cn; Fax: +86-22-87401895; Tel: +86-22-87401895
cCollege of Pharmacy, Henan University, Kaifeng, 475001, China
dChemistry Department, Henan University, Kaifeng, 475001, China
First published on 13th March 2024
Abstract
Expression of Concern for ‘Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway’ by Zhi-Yong Tian et al., Org. Biomol. Chem., 2009, 7, 4651–4660, https://doi.org/10.1039/B912685F.
Organic & Biomolecular Chemistry is publishing this expression of concern in order to alert our readers that we are presently unsure of the reliability of the Western blot data reported in Fig. 5b–d, 6d and 7, and the control FACS data in Fig. 4b.
The control FACS data in Fig. 4b is identical to the control FACS data in Fig. 2a of ref. 1.
The authors have repeated the Western blot experiments and provided new data but the replacement data does not meet experimental data requirements.
An expression of concern will continue to be associated with the article until we receive conclusive evidence regarding the reliability of the results.
Katie Lim
01/03/2024
Executive Editor, Organic & Biomolecular Chemistry
References
- S. Xie, Q. Li, Y. Zhang, J. Wang, Z. Mei, J. Zhao and C. Wang, Apoptosis, 2011, 16, 27–34 CrossRef CAS PubMed.
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