Na2CO3-promoted synthesis of thiocarbamates from isocyanates and thiols under mild conditions

Abstract

Here, we developed an efficient method for the synthesis of s-alkyl or aryl thiocarbamates catalyzed by Na₂CO₃ under mild conditions using alkyl or aryl isocyanates and thiophenols or thiols. In situ reaction with deuterated tetrahydrofuran (d₈-THF) was carried out to investigate the reaction mechanism. This method has the advantages of high yield, good functional group tolerance and high atom economy.