Issue 31, 2024

Modular synthesis of 3,3-disubstituted oxindoles from nitrones and acrylic acids

Abstract

We developed a modular synthesis for 3,3-disubstituted oxindoles, utilising readily accessible nitrones and acrylic acids. This approach facilitates the preparation of a diverse array of oxindoles through the variation of the starting materials. We demonstrated the applicability of this method through a gram-scale reaction and a synthesis of esermethole.

Graphical abstract: Modular synthesis of 3,3-disubstituted oxindoles from nitrones and acrylic acids

Supplementary files

Article information

Article type
Communication
Submitted
07 Jun 2024
Accepted
13 Jul 2024
First published
16 Jul 2024

Org. Biomol. Chem., 2024,22, 6282-6287

Modular synthesis of 3,3-disubstituted oxindoles from nitrones and acrylic acids

H. Suzuki, K. Sekino, S. Kondo, R. Minamikawa and T. Matsuda, Org. Biomol. Chem., 2024, 22, 6282 DOI: 10.1039/D4OB00964A

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