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Retraction: Dealcoholized muscadine wine was partially effective in preventing and treating dextran sulfate sodium-induced colitis and restoring gut dysbiosis in mice
Hao
Li
a,
Lindsey M.
Christman
a,
Yavuz
Yagiz
a,
Taylor L.
Washington
a,
Gary P.
Wang
b and
Liwei
Gu
*a
aFood Science and Human Nutrition Department, College of Agricultural and Life Sciences, USA. E-mail: Lgu@ufl.edu
bDivision of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, Florida 32611, USA
First published on 29th February 2024
Abstract
Retraction of ‘Dealcoholized muscadine wine was partially effective in preventing and treating dextran sulfate sodium-induced colitis and restoring gut dysbiosis in mice’ by Hao Li et al., Food Funct., 2023, 14, 5994–6011, https://doi.org/10.1039/D3FO00047H.
We, the first and corresponding authors, hereby wholly retract this Food & Function article. It has come to our attention that incorrect statistical methods were used to compare values in different treatment groups. We have confirmed that the majority of the significant differences reported in the initial submission had high risks of being false positives due to the lack of control for family-wise error rate and multiple-comparison adjustment of p values. This is a result of honest errors made in the data analysis.
The claims in the article that DMW affected serum levels of IL-1β, IL-6, IL-1β mRNA, TNF-α mRNA, FITC permeability, p-Ikb-α/Ikb-α protein ratio, ZO-1 mRNA, occludin protein, and cecum SCFA should be disregarded. It is now believed that the activity of DMW was much weaker than initially reported. It appeared that DMW in all three groups decreased the MPO activity in the colon of colitis mice. DMW in the treatment group prevented colon shortening compared to the colitis group. DMW in the treatment and P + T groups improved the histological score of the colon compared to the colitis group. DMW in the P + T group partially restored gut dysbiosis in colitis mice as reflected by diversity and differentially enriched taxa in the gut.
All co-authors agree to this retraction.
Signed: Hao Li and Liwei Gu
Date: 23rd February 2024
Retraction endorsed by Rebecca Garton, Executive Editor, Food & Function
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