Lukas
Körner
,
Dirk
Bockfeld
,
Thomas
Bannenberg
and
Matthias
Tamm
*
Institut für Anorganische und Analytische Chemie, Technische Universtiät Braunschweig, Hagenring 30, 38106 Braunschweig, Germany. E-mail: m.tamm@tu-bs.de
First published on 8th July 2024
The reaction of dipiperidinoacetylene, (CH2)5NCCN(CH2)5, with a series of 2,3-diarylcyclopropenones (Ar)2C3O (Ar = phenyl, 4-tert-butylphenyl, 2,5-dimethylphenyl, 4-trifluoromethylphenyl) afforded 2,3-dipiperidino-4,5-diarylcyclopentadienones, which were used to prepare cyclopentadienone (CPD) iron tricarbonyl complexes [(CPD)Fe(CO)3] by the reaction with Fe2(CO)9. Subsequent treatment with trimethylamine-N-oxide in the presence of acetonitrile afforded the corresponding acetonitrile complexes [(CPD)Fe(CO)2(NCCH3)], which were used as catalysts for the reductive amination of citronellal with various secondary amines under 5 bar of dihydrogen pressure. The first iron-catalysed reductive amination for the preparation of the pharmaceutically important antidepressant sertraline is also reported.
In contrast, more electron-rich amino-substituted congeners are rare, with only two classes known to date (Fig. 1, I and II). As early as 1966, the uncatalysed (3 + 2)-cycloaddition of 1-diethylamino-2-phenylacetylene with diphenylcyclopropenone was shown to yield 3-diethylamino-2,4,5-triphenylcyclopentadienone.21 In 1980, this reaction type was used to obtain a larger series of 3-amino-2,4,5-triaryl-CPD derivatives I.22 The proposed mechanism involves a nucleophilic attack by the aminoalkyne on the carbonyl group of the cyclopropenone, which is then followed by an electrocyclic rearrangement to form the CPD. In 2007, Haak introduced the first and only known synthesis of diamino-CPDs. Among these, the bicyclic compound II is preferably used for the preparation of catalysts and can be obtained in two steps from 1,3-diphenylpropan-2-one, diethyl oxalate, and N,N-dimethylethylenediamine.23 The CPD can then be transferred to ruthenium or iron by reacting it with suitable precursors, such as Ru3(CO)12 or Fe2(CO)9.24,25 The use of CPD complexes as catalysts originated from the discovery of the Shvo catalyst; this bimetallic hydride-bridged CPD ruthenium dimer was discovered as the reaction product of diphenylacetylene and Ru3(CO)12. Shvo and coworkers demonstrated that the catalyst dissociates in solution, providing both a hydrogen acceptor and a hydrogen donor.24 This property enables broad applicability in catalytic oxidation and reduction reactions through dehydrogenation and hydrogenation, respectively.26,27
Related CPD iron complexes, despite their first appearance as early as the 1950s (vide supra),4–7 only became the target of catalytic applications after 1999, when Knölker published the preparation of the hydroxy–hydride complex III (Fig. 1) through a Hieber-base type transformation of the corresponding iron CPD tricarbonyl complex with sodium hydroxide, followed by an acidic workup with H3PO4.28 Casey and Guan were the first to use III for catalytic purposes. They investigated the (transfer-)hydrogenation of various carbonyl compounds and one imine and also provided mechanistic insights by substantiating the widely accepted “outer-sphere” mechanism for the dihydrogen transfer, which involves the hydroxy–hydride complex as the catalytically active species.29,30 For most CPD-iron catalyst systems, however, the active catalyst is typically generated from a stable CPD iron tricarbonyl complex, which is achieved by dissociating one CO ligand, either chemically with trimethylamine-N-oxide or photochemically by UV irradiation. The resulting unsaturated species then forms the corresponding hydroxy–hydride complex upon reacting with the hydrogen donor.31–33 Alternatively, direct activation with the hydrogen donor can be achieved by using the corresponding dicarbonyl complexes that contain a labile ligand, such as acetonitrile, which can be readily dissociated in situ.34
As part of our research on the chemistry of diaminoacetylenes (DAAs),35–40 we have recently introduced various symmetric and asymmetric tetraamino-CPD iron complexes of type IV (Fig. 1) with cyclic amino substituents such as piperidine. These complexes were obtained by reacting two DAA equivalents with Fe(CO)5, followed by CO substitution with the acetonitrile ligand.41 As previously shown by Filippou,42 these reactions proceed via a ferracyclobutenone intermediate, which allows the subsequent incorporation of two different DAA units (NR2 ≠ , Fig. 1). Investigation of the catalytic activity of these complexes in the (transfer-)hydrogenation of carbonyl compounds revealed a significantly enhanced catalytic activity compared to the established Knölker-type congeners. In particular, the hydrogenation of aldehydes and ketones with dihydrogen proceeded under remarkably mild reactions conditions (3 bar dihydrogen pressure, room temperature). Attempts to isolate a hydroxy–hydride intermediate similar to III proved unsuccessful, and its relative thermodynamic instability compared to its dehydrogenated form was confirmed by DFT calculations.41 It should also be noted that our recent attempts to decompose complexes IV or their Fe(CO)3 precursors to release the as yet inaccessible free 2,3,4,5-tetraamino-CPDs were also unsuccessful.
Since enhanced catalytic activity was also observed by Renaud and coworkers for 3,4-diamino-CPD iron complexes derived from II,25,43–50 we reasoned that 2,3-diamino-CPDs 3 should also give rise to promising CPD iron catalysts and that they should be readily accessible from diarylcyclopropenones and diaminoacetylenes (DAAs), in analogy to similar reactions with monoaminoalkynes to give CPDs I.21,22 Accordingly, we report here the preparation of various 2,3-diamino-4,5-diarylcyclopentadienones 3 and their corresponding CPD-iron complexes 5, which were used as catalysts in hydrogenation and reductive amination reactions (see box in Fig. 1). It should be noted that the metal coordination of CPDs 3via their enantiotopic faces affords planar chiral metal complexes which, upon resolution, could serve as stereoselective hydrogenation catalysts, an area that has received comparatively little attention in the case of CPD iron complexes.51–59 The best results so far, however, have not been obtained with chiral CPD complexes, but with Knölker's catalyst III in combination with chiral BINOL-derived phosphoric acids, and these systems have been used by Beller and coworkers in the asymmetric hydrogenation and reductive amination reactions with high enantiomeric excesses.60–63
In contrast, di(4-tert-butylphenyl)cyclopropenone (2b) and bis(2,5-dimethylphenyl)cyclopropenone (2c) underwent a colour change when treated with dipiperidinoacetylene (1) at ambient temperature over a few hours. The resulting purple substances were isolated by column chromatography and characterised by NMR spectroscopy. The NMR spectra of cyclopentadienone 3b exhibited the expected signals, whereas 3c produced more signals than anticipated. This observation can be attributed to hindered rotation around the C4/5–Caryl bonds and the presence of diastereomeric atropisomers in solution at ambient temperature (ESI,† Fig. S6). Variable-temperature 1H NMR spectra were recorded in tetrachloroethene up to 100 °C, however, coalescence and fast interconversion could not be observed (ESI,† Fig. S8). The structural integrity of 3c is supported by the recorded IR and UV/Vis spectra as well as from the ESI high-resolution mass spectrum. Another CPD, 3d, was synthesized in a similar fashion from bis(4-trifluoromethylphenyl)cyclopropenone (2d), but at lower temperature due to the higher reactivity of the CF3-substituted, less electron-rich cyclopropenone. 3d was characterized, inter alia, by NMR spectroscopy, including the 19F NMR spectrum, which showed two singlets at −63.0 and −63.1 ppm.
Furthermore, the molecular structures of 3a and 3d could be determined by X-ray diffraction analysis after growing suitable single crystals from diethylether/n-hexane and n-hexane solutions, respectively, both at −40 °C. The molecular structure of 3a is shown in Fig. 2, while that of 3d is presented in the ESI† section (Table S2). In both structures, the C3–N2 bond lengths are significantly shorter than the corresponding C2–N1 bonds, i.e. 1.3604(17) vs. 1.4277(13) Å in 3a, indicating a significant double bond character of the C3–N2 bonds. Furthermore, the C1–C2 bonds are shortened compared to the C1–C5 bonds and the angle sums of the nitrogen atoms show planarised N2 atoms (356.6 in 3a). This suggests a significant π-interaction with the N2 lone pair and consequently a marked polarisation towards an imininium-enolate mesomeric form.
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Fig. 3 Calculated energy profiles (a in black, b in red) for the formation of 2,3-dipiperidinyl-4,5-diphenylcyclopentadienone (3a) from dipiperidinoacetylene (1) and diphenylcyclopropenone (2a), scaled to standard Gibbs free energies (ΔG°); standard enthalpies are given in square brackets. The densitiy functional theory (DFT) method ωB97XD/6-311G(d,p) together with a universal solvent model (SMD) for toluene was used (ESI†). |
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Scheme 2 Synthesis of 2,3-dipiperidino-4,5-diarylcyclopentadienone iron complexes 4 from free CPDs 3 and transformation to corresponding acetonitrile complexes 5. |
The CPD complexes exhibit markedly different solubilities; the phenyl-substituted complex 4a is almost insoluble in unpolar media such as n-hexane, whereas the addition of substituents to the phenyl moieties increases the solubility. Accordingly, single crystals suitable for X-ray diffraction analysis could be obtained from a THF/n-hexane solution for 4a, chloroform/n-hexane for 4b·CHCl3, hot n-hexane by cooling to room temperature for 4c, and a saturated cyclohexane solution of 4d·cyclohexane at ambient temperature. The molecular structure of 4a is shown in Fig. 4, while those of 4b–4d are presented in the ESI† section (Tables S4–S6). Relevant bond lengths of the four tricarbonyl complexes are summarised in Table 1 for comparison. All complexes exhibit the expected three-legged piano-stool geometry around the iron atoms with η4-coordinated CPD ligands that have slightly longer Fe–Cpip (2.18–2.22 Å) than Fe–Caryl (2.05–2.11 Å) bond lengths. The Fe–C1 distances are significantly longer (2.40–2.46 Å) with the CO units bending away from the iron atoms, precluding any significant binding interaction. Accordingly, short C1–O bond lengths of about 1.23 Å are found. It is noteworthy that the C2–N1 and C3–N2 bond lengths are uniform (∼1.39 Å) and both nitrogen atoms are clearly pyramidalised in each case, in contrast to the markedly different nitrogen environments found in the free CPD ligands (vide supra). Overall, however, the structural parameters are in very good agreement with those determined for other CPD complexes, especially those with amino substituents.25,41,42
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Fig. 4 Molecular structures of 4a (top) and 5a (bottom) with thermal displacement parameters drawn at 50% probability. Hydrogen atoms as well as a toluene molecule in the asymmetric unit of 5a·toluene are omitted for clarity. Selected bond lengths are listed in Table 1. |
4a | 4b | 4c | 4d | 5a | 5b | 5c | 5d | 6 | |
---|---|---|---|---|---|---|---|---|---|
a The bond lengths of the two independent molecules in the asymmetric unit are shown.
b Distance between Fe1 and the centroid of C2–C3–C4–C5 is shown.
c L = C28![]() |
|||||||||
Fe–CPDb | 1.7760(9) | 1.7807(9) | 1.7783(4) | 1.8228(10)/1.7789(11) | 1.7526(7) | 1.7692(13) | 1.7812(3) | 1.7653(14) | 1.7706(5) |
Fe–Lc | 1.805(2) | 1.8094(13) | 1.7998(7) | 1.803(2)/1.803(2) | 1.9543(13) | 1.951(3) | 1.9458(3) | 1.951(2) | 1.9752(10) |
Fe–C29O | 1.7994(19) | 1.7975(18) | 1.8036(6) | 1.795(2)/1.798(3) | 1.7843(10) | 1.774(3) | 1.784(2) | 1.781(4) | 1.7860(11) |
Fe–C30O | 1.7962(16) | 1.8025(18) | 1.7930(7) | 1.8038(18)/1.8049(17) | 1.7826(17) | 1.785(3) | 1.783(2) | 1.795(3) | 1.7737(10) |
Fe–C2 | 2.2210(15) | 2.2185(17) | 2.2072(6) | 2.225(2)/2.220(2) | 2.1994(14) | 2.202(3) | 2.238(2) | 2.200(2) | 2.1244(9) |
Fe–C3 | 2.1842(14) | 2.1891(16) | 2.1874(5) | 2.204(2)/2.205(2) | 2.1265(14) | 2.150(3) | 2.1678(18) | 2.166(2) | 2.121(1) |
Fe–C4 | 2.0707(16) | 2.0660(14) | 2.0634(6) | 2.0503(19)/2.059(2) | 2.0557(14) | 2.046(3) | 2.0605(18) | 2.028(3) | 2.1700(9) |
Fe–C5 | 2.0724(16) | 2.0986(16) | 2.1112(6) | 2.0846(17)/2.0819(17) | 2.090(1) | 2.134(3) | 2.098(2) | 2.118(4) | 2.1180(9) |
C1–C2 | 1.505(2) | 1.495(2) | 1.5042(5) | 1.503(2)/1.502(2) | 1.4955(13) | 1.487(5) | 1.485(3) | 1.488(5) | 1.4751(12) |
C2–C3 | 1.451(3) | 1.4494(17) | 1.4520(7) | 1.452(3)/1.453(3) | 1.4469(16) | 1.441(4) | 1.450(2) | 1.442(4) | 1.4428(2) |
C3–C4 | 1.4426(19) | 1.445(2) | 1.4478(7) | 1.445(2)/1.449(3) | 1.4407(16) | 1.445(3) | 1.443(3) | 1.446(4) | 1.4431(12) |
C4–C5 | 1.450(3) | 1.449(2) | 1.4573(5) | 1.452(3)/1.453(3) | 1.4465(15) | 1.453(5) | 1.446(3) | 1.449(4) | 1.4418(12) |
C5–C1 | 1.469(3) | 1.4719(18) | 1.4736(8) | 1.478(3)/1.477(3) | 1.4688(16) | 1.473(4) | 1.462(3) | 1.467(4) | 1.4775(12) |
C1–O1 | 1.227(3) | 1.2375(17) | 1.2316(6) | 1.229(3)/1.235(3) | 1.2382(13) | 1.240(4) | 1.240(2) | 1.238(4) | 1.2373(11) |
C2–N1 | 1.385(2) | 1.3900(17) | 1.3892(8) | 1.389(2)/1.392(3) | 1.3956(14) | 1.398(3) | 1.385(3) | 1.397(4) | 1.3850(11) |
C3–N2 | 1.386(2) | 1.386(2) | 1.3852(5) | 1.385(2)/1.380(2) | 1.4010(14) | 1.395(4) | 1.387(2) | 1.385(4) | 1.3727(12) |
C4–Ci | 1.488(3) | 1.4878(16) | 1.4951(7) | 1.487(3)/1.490(3) | 1.4879(16) | 1.495(4) | 1.495(3) | 1.493(4) | 1.4738(12) |
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1.486(2) | 1.484(2) | 1.4888(6) | 1.479(2)/1.477(3) | 1.4780(15) | 1.482(4) | 1.494(3) | 1.480(5) | 1.4861(12) |
For the application of iron CPD complexes in homogeneous catalysis, a coordinatively unsaturated species must be provided by dissociation of one carbonyl ligand. For this purpose, in situ activation by treatment with trimethylamine-N-oxide (Me3NO) is widely used in the literature, but according to our studies on tetraamino-cyclopentadienone iron complexes, the preparation of the corresponding dicarbonyl-acetonitrile complexes is a more favourable method to obtain sufficiently active precatalysts.41 The tricarbonyl complexes 4 were therefore treated with Me3NO in a toluene/acetonitrile mixture (10:
1) at ambient temperature to effect the oxidation of a carbonyl ligand to carbon dioxide and its substitution by the acetonitrile ligand (Scheme 2). The complexes 5 could be isolated as analytically pure orange solids in moderate yields (50–65%) after recrystallization from toluene/n-hexane mixtures (5a–5c) or acetonitrile (5d). NMR spectroscopic characterisation in CD2Cl2 revealed characteristic additional signals for the coordinated acetonitrile ligands at ca. 2.2 ppm (CH3) in the 1H NMR spectra and at ca. 127 ppm (CN) and 4.8 ppm (CH3) in the 13C{1H} NMR spectra, in good agreement with the chemical shifts reported for the corresponding tetraamino-CPD complexes IV.41 In contrast to symmetric complexes of the latter type, complexes 5 are asymmetric, resulting in two distinct signals for the two remaining diastereotopic carbonyl ligands, found at 216.0/214.1 (5a), 216.1/214.3 (5b), 217.4/214.1 (5c), and 215.2/213.4 ppm (5d), respectively. Again, the 1H and 13C{1H} NMR spectra of the xylyl-substituted CPD complex 5c show four sharp signals for the o-CH3 and m-CH3 groups of the two different xylyl substituents, indicating rapid interconversion between the four possible atropisomers at room temperature on the NMR time scale. The IR spectra of complexes 5 exhibit two equally strong CO absorption bands with averaged CO stretching frequencies (
av) of 1954 (5a), 1952 (5b), 1949 (5c), and 1959 cm−1 (5d). These values are slightly higher than those determined for the tetraamino congeners IV (
av ≈ 1944 cm−1),41 which is consistent with reduced metal-carbonyl π-backbonding in the presence of diamino- rather than tetraamino-CPD ligands.
For comparison, the diamino-CPD iron dicarbonyl acetonitrile complex [(II)Fe(CO)2(NCMe)] (6, Fig. 5, vide infra) was synthesised from the corresponding tricarbonyl complex [(II)Fe(CO)3], as only the latter has previously been used as a precatalyst by in situ activation with Me3NO.25,43,506 was isolated as an orange solid in 75% yield following the same procedure described for complexes 5. Here, the 1H and 13C{1H} NMR signals of the acetonitrile ligand are found at 2.14 ppm (CH3) and at 125.8 ppm/4.6 ppm (CN, CH3). The IR spectrum of 6 allows to establish an averaged CO stretching frequency of av(CO) = 1940 cm−1, indicating a stronger π-electron releasing ability of the bicyclic 3,4-diamino-CPD ligand II compared to the 2,3-diamino-CPD ligands 3 and consequently an enhanced metal-carbonyl π-backbonding interaction.
The molecular structures of all five acetonitrile complexes were determined by X-ray diffraction analysis of suitable single crystals isolated from toluene/n-hexane solutions (5a·toluene, 5c·0.7 toluene·0.3 hexane), from an n-hexane solution (5b·0.5 hexane) or from an acetonitrile solution (5d), each at −40 °C. The molecular structure of 5a is shown in Fig. 4, all other structures are presented in the ESI† section (Tables S8–S11). Selected bond lengths are given in Table 1. All complexes exhibit the expected three-legged piano-stool geometry, with an ecliptic orientation of the acetonitrile ligand towards the CPD carbonyl group, as found in all other previously structurally characterised complexes of the type [(CPD)Fe(CO)2(NCMe)],64,65 including the tetraamino-CPD congeners IV.41 As observed for 4a–4d (vide supra, Table 1), the η4-coordinated CPD ligands in 5a–5d again have slightly longer Fe–Cpip (2.20–2.24 Å) than Fe–Caryl (2.05–2.13 Å) bond lengths. Complex 6, on the other hand, shows a more symmetrical binding with Fe–C bond lengths ranging from 2.1180(9) to 2.1700(9) Å. The Fe–N bond lengths in 5a–5d are ca. 1.95 Å, while a slightly longer bond length of 1.9752(10) Å is found for 6.
Varying the reaction conditions showed that complex 5a is able to promote the reaction at elevated temperature (85 °C) under 5 bar dihydrogen pressure to achieve full conversion to amine 10 at 1 mol% catalyst loading (Table 2, entries 1–4). Further reduction of the catalyst loading to 0.5 mol% resulted in a slight decrease in conversion to 88% (entry 5). Attempts to perform the reaction at atmospheric dihydrogen pressure or in toluene at ambient temperature resulted only in the formation of the intermediate enamine 9, with no further conversion to the desired amine 10 (entries 6 and 7). The former observation, however, rules out the ethanol solvent as a possible transfer hydrogenation reagent to any significant extent. The diamino-CPD derivatives 5b, 5c and 5d were also successfully applied and performed just as well as 5a (entries 4 and 8–10). In contrast, the tetraamino-CPD complex IVa gave full conversion at a lower temperature (45 °C), but no reactivity was observed at ambient temperature (entries 11 and 12). This performance is similar to that of precatalyst 6, which promoted the reaction efficiently at 85 °C and 45 °C with catalyst loadings of 1 and 2.5 mol%, respectively (entries 13 and 14). The latter reactivity agrees with the results reported by Renaud for the corresponding tricarbonyl complex, albeit activated in situ with trimethylamine-N-oxide.43 Finally, the non-nitrogen substituted Knölker-type complex 7 proved to be less reactive even at elevated temperature (entry 15). It can therefore be concluded that amino substituents on the CPD ring are clearly favourable for catalytic activity, with both tetraamino and 3,4-diamino substitution leading to improved catalytic activity compared to 2,3-diamino substitution.
Entry | [Fe] | Mol% | H2 | Solvent | Temp. | Conv.a |
---|---|---|---|---|---|---|
Reaction conditions: 0.5 mmol citronellal, 0.6 mmol N-methylbenzylamine, 1 mL solvent, 16 h.a Conversion determined by GC/MS, isolated yield in brackets. | ||||||
1 | 5a | 2 | 5 bar | EtOH | rt | 1% |
2 | 5a | 2 | 5 bar | EtOH | 45 °C | 2% |
3 | 5a | 2 | 5 bar | EtOH | 85 °C | >99% |
4 | 5a | 1 | 5 bar | EtOH | 85 °C | >99% (89%) |
5 | 5a | 0.5 | 5 bar | EtOH | 85 °C | 88% |
6 | 5a | 1 | 1 atm | EtOH | 85 °C | 0% |
7 | 5a | 2 | 5 bar | Toluene | rt | 0% |
8 | 5b | 2 | 5 bar | EtOH | 85 °C | >99% |
9 | 5c | 1 | 5 bar | EtOH | 85 °C | >99% |
10 | 5d | 1 | 5 bar | EtOH | 85 °C | >99% |
11 | IVa | 2 | 5 bar | EtOH | 45 °C | >99% (93%) |
12 | IVa | 2 | 5 bar | EtOH | rt | 0% |
13 | 6 | 1 | 5 bar | EtOH | 85 °C | >99% |
14 | 6 | 2.5 | 5 bar | EtOH | 45 °C | >99% |
15 | 7 | 2 | 5 bar | EtOH | 85 °C | 92% |
To expand the substrate range for the new catalysts, various analogous reductive amination reactions were carried out using different secondary amines, 5 bar dihydrogen pressure, 2 mol% 5a and 85 °C in EtOH for 16 h (Scheme 3). Fortunately, the piperazyl pyrimidine derivative 11 was obtained in a high isolated yield of 95%. An equally excellent yield was achieved using (S)-prolinol methyl ether and 12 was isolated in 94% yield, but complete racemisation was observed due to the formation of an intermediate enamine containing the asymmetrically substituted carbon atom. Accordingly, the NMR signals for the two diastereomers are found (ESI†). In contrast, diphenylamine showed no conversion to the intermediate enamine, but a complete hydrogenation of citronellal to citronellol, tentatively attributed to the steric demand of the amine and the resulting slow enamine formation. When N-methylaniline was used instead, 30% conversion to the desired amine 14 was observed, but 70% citronellol was still obtained. The same problem was encountered with dicyclohexylamine targeting amine 15, whereas dibenzylamine was suitable to produce amine 16 with complete conversion. Using an ethanolic dimethylamine solution, 31% of the desired amine 17 was obtained, which could potentially be improved by increasing the excess of the gaseous amine. Of note, amine 18 was successfully synthesised with full chemoselectivity and no reduction of the allyl CC double bonds in the diallylamino group was observed. The presence of additional hydroxy groups using diisopropanolamine did not appear to be a problem either and amine 19 could be obtained in high yield (97%). Finally, the reductive amination of citronellal with indoline was tested, with the expectation that an aromatic indole derivative might be formed as an intermediate. Fortunately, the desired amine 20 was obtained in 79% yield and according to the GC/MS analysis the aromatic enamine was present in only 4%.
Reductive amination is one of the most important classes of reactions in the production of substances in demand for pharmaceutical and medicinal applications.70 At the same time, sustainable strategies that replace precious metals, harsh reaction conditions and environmentally unfriendly solvents are becoming increasingly important.71 Furthermore, the search for chiral catalysts that allow asymmetric transformations to yield enantiomerically pure substances has become an increasingly demanded field in order to reduce waste in terms of stereoisomeric by-products and also the need for enantioselective separation.72 With the asymmetric CPD iron hydrogenation catalysts 5 in hand, the opportunity to contribute to this important field seems possible after the separation of the racemic mixtures obtained in the reaction of the CPDs 3 with Fe2(CO)9. As a first attempt to assess the general suitability of the planar chiral complexes 5 for the preparation of a chiral drug, we chose sertraline, the (S,S)-enantiomer of 22 (Scheme 4), which is one of the most demanded drugs for the treatment of mood and anxiety disorders.73 The key transformation is the reductive amination of the racemic tetralone derivative 21 with H2 over Pd/C, patented by Pfizer Inc.,74,75 which is used industrially. The desired enantiomer is then separated by crystallisation with (R)-mandelic acid.73,76 In order to apply our new iron catalysts to this transformation, we reacted the racemic tetralone derivative 21 with methylamine over molecular sieves in ethanol for 48 h and observed a complete conversion to the corresponding imine. Subsequently, reduction under 5 bar H2 in ethanol for 16 h led to a complete hydrogenation to the corresponding amine 22 with a diastereomeric ratio of 63:
37 (cis
:
trans), which is comparable to those achieved in the industrial process (70
:
30).74 Thus, this application demonstrates a promising and potentially green alternative by replacing the solvent tetrahydrofuran with ethanol and a palladium catalyst with an iron catalyst. The potential for asymmetric hydrogenation using enantiomerically pure derivatives of our catalyst after chiral resolution is currently being investigated.
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Scheme 4 Reductive amination to afford sertraline; reaction conditions: 6 eq. MeNH2, 1 g mmol−1 molecular sieves (3–5 Å), 2 mol% 5a. |
Footnote |
† Electronic supplementary information (ESI) available. CCDC 2338289–2338299. For ESI and crystallographic data in CIF or other electronic format see DOI: https://doi.org/10.1039/d4cy00372a |
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