Correction: Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance

Mun Juinn Chow; Cynthia Licona; Giorgia Pastorin; Georg Mellitzer; Wee Han Ang; Christian Gaiddon

doi:10.1039/D3SC90157B

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DOI: 10.1039/D3SC90157B (Correction) Chem. Sci., 2023, 14, 9608-9609

Correction: Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance

Mun Juinn Chow ^ab, Cynthia Licona ^cd, Giorgia Pastorin ^be, Georg Mellitzer ^cd, Wee Han Ang *^ab and Christian Gaiddon *^cd
^aDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore. E-mail: chmawh@nus.edu.sg; Tel: +65 6516 5131
^bNUS Graduate School for Integrative Sciences and Engineering, Singapore
^cU1113 INSERM, 3 Avenue Molière, Strasbourg 67200, France. E-mail: gaiddon@unistra.fr; Tel: +33 68 52 53 56
^dSection Oncology, FMTS, Strasbourg University, Strasbourg, France
^eDepartment of Pharmacy, National University of Singapore, 18 Science Drive 4, 117543, Singapore

Received 11th August 2023 , Accepted 11th August 2023

First published on 29th August 2023

Abstract

Correction for ‘Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance’ by Mun Juinn Chow et al., Chem. Sci., 2016, 7, 4117–4124, https://doi.org/10.1039/C6SC00268D.

The authors regret that an incorrect version of Fig. 3 was included in the original article, where two incorrect images were used, namely RAS-1H LD treatment and RAS-1H HD treatment, resulting in an unintentional duplication. The correct version of Fig. 3 is presented here, which is now consistent with Fig. S5a from the ESI of the original publication.

Fig. 3 Complexes RAS-1H and RAS-1T induce early time-point ROS and activate cellular antioxidant defense mechanism. (a) Detection of ROS with carboxy-H₂DCFDA (20 μM) after treatment with RAS-1H and RAS-1T for 3 h, 6 h and 9 h using a microplate assay. Mean ± s.e.m. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; Student's t test). (b) Detection of ROS with a fluorescence microscope after treatment for 6 h. (c) Western blot analysis of Nrf-2, a central protein in cellular antioxidant defence and (d) expression levels of Nrf-2 target gene in AGS cells after treatment with RAS-1H, RAS-1T and cisplatin at LD and HD for 6 h and 24 h. Homogeneous protein loading determined with reference to actin and gene expression normalized against tbp levels.

The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.