Issue 11, 2023

Plant-derived chelators and ionophores as potential therapeutics for metabolic diseases

Abstract

Transition metal dysregulation is associated with a host of pathologies, many of which are therapeutically targeted using chelators and ionophores. Chelators and ionophores are used as therapeutic metal-binding compounds which impart biological effects by sequestering or trafficking endogenous metal ions in an effort to restore homeostasis. Many current therapies take inspiration or derive directly from small molecules and peptides found in plants. This review focuses on plant-derived small molecule and peptide chelators and ionophores that can affect metabolic disease states. Understanding the coordination chemistry, bioavailability, and bioactivity of such molecules provides the tools to further research applications of plant-based chelators and ionophores.

Graphical abstract: Plant-derived chelators and ionophores as potential therapeutics for metabolic diseases

Article information

Article type
Review Article
Submitted
06 Mar 2023
First published
19 May 2023

Chem. Soc. Rev., 2023,52, 3927-3945

Author version available

Plant-derived chelators and ionophores as potential therapeutics for metabolic diseases

V. J. Lee, S. E. Janisse and M. C. Heffern, Chem. Soc. Rev., 2023, 52, 3927 DOI: 10.1039/D3CS00167A

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