Boris V.
Goikhman
a,
Fedor S.
Fedorov
*a,
Nikolay P.
Simonenko
b,
Tatiana L.
Simonenko
b,
Nikita A.
Fisenko
bc,
Tatiana S.
Dubinina
a,
George
Ovchinnikov
a,
Anna V.
Lantsberg
d,
Alexey
Lipatov
e,
Elizaveta P.
Simonenko
b and
Albert G.
Nasibulin
*af
aSkolkovo Institute of Science and Technology, 3 Nobel Str., Moscow, 121205, Russian Federation. E-mail: f.fedorov@skoltech.ru; a.nasibulin@skoltech.ru
bKurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, 31 Leninsky pr., Moscow 119991, Russian Federation
cD. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya sq., Moscow 125047, Russian Federation
dBauman Moscow State Technical University, 5/1 Baumanskaya 2-ya Str., Moscow, 105005, Russian Federation
eSouth Dakota School of Mines and Technology, 501 E. Saint Joseph St., Rapid City, SD 57701, USA
fAalto University, Kemistintie 1, P.O. Box 16100, 00076 Aalto, Finland
First published on 7th March 2022
Tracing the chemical composition of the surrounding environment appeals to the design of highly sensitive and selective gas sensors. Primarily driven by IoT, miniaturized multisensor systems, like e-noses, are considered to address both selectivity and sensitivity issues. Although e-noses might enable discrimination between close homologs and isomers, they are required to be “trained”, i.e. to project analyte-related signals into artificial space, prior to their in-field applications. In this study, using the programmed co-precipitation method, we synthesized aluminum-doped zinc oxide (AZO) and employed it as a sensing material in an e-nose to examine the sensing performance towards close C1–C5 alcohol homologs and isomers, e.g. 1-propanol and 2-propanol, 1-butanol and isobutanol in the frame of the multisensor paradigm. For the first time, we demonstrated selective recognition of the alcohol vapors without prior training of the e-nose. This was realized by matching projections of the known analytes' “fingerprints”, used to build a chemical space, with the projections of analyte-related signals acquired using the e-nose in artificial space under machine learning algorithms. Moreover, the AZO based e-nose demonstrates a remarkable, up to 0.87, chemoresistive response to alcohol vapors, 0.9 ppm, in the mixture with air at 300 °C with a detection limit down to sub-ppb level. This opens a new avenue for the development of self-learning gas analytical systems, which might recognize new analytes whose profiles are not yet stored in their library.
The analytical figure of merit of every sensor or gas analytical system is defined by several parameters, such as sensitivity, selectivity, stability, speed of operation, cross-sensitivity, limit of detection, etc.8–10 A natural primary ambition is to achieve maximum performance for a sensor, e.g. detection of a single molecule is an ultimate characteristic of sensor sensitivity.11 The other important characteristic, i.e. the ultimate selectivity, should address differentiation between two isomers or very close homologs, still complicated by undeveloped approaches to the description of the basis of the smell.12,13
Several analytical techniques meet the demands for selective detection of isomers or homologs, such as photoacoustic sensors, which also enable sensitivity down to sub-ppt level,14 sensors based on Fourier-transform infrared spectroscopy (FTIR), which enable recognition of many analytes in the wavelength region of molecular fingerprints,15 ion mobility mass spectrometry (IMS),16 also mass spectrometry (MS) coupled with liquid or gas chromatography (GC).17 While traditional MS methods handle the differentiation of particles using a mass-to-charge ratio, drift time IMS separation is directly based on particle collision cross-section,18,19 enabling the determination of isomers. In 2019 Ono et al. reported a vapochromic sensor for discrimination of small aromatic molecules.20 Their device was proved to have good sensitivity to 1 ppm of toluene, p-xylene, 4-fluorotoluene, and anisole. The high selectivity of the device allowed one to differentiate between the different isomers of xylene. A combination of gas sensors with a chromatographic column has been utilized to approach selective recognition of close homologs. In 2006 Sanches et al. reported a volatile organic compound (VOC) detection device based on a single gas sensor combined with a GC micro-column with very high selectivity and with low response time.21 Thirteen years later van den Broek et al. revived this approach for the separation of methanol over ethanol.3 Recently, metal–organic frameworks have attracted considerable attention relying on highly selective adsorption capabilities.22 In 2021 Kumar et al. demonstrated a highly selective ethanol sensor made by growing a surface-mounted metal–organic framework directly onto graphene field-effect transistors.23
Alternatively, selective gas analytical systems are designed employing the principles of biological systems. First proposed by Persaud and Dodd,24 a classical electronic nose (e-nose) mimics the operation of the mammalian olfactory system, i.e. in e-nose, sensors collected in an array, provide a distinct response pattern towards a target analyte.25,26 This vector response represents a “fingerprint” of the analyte, to be further processed by pattern recognition algorithms for its selective determination.27–30 Such a gas analytical system has been proven suitable for the discrimination of close homologs.31 Using MOFs, the e-nose approach enhanced with machine learning yields enantioselective detection and discrimination of chiral molecules.32 Unlike many other techniques requiring bulky apparatus, an e-nose is often made following the lab-on-chip paradigm.31,33 At this standpoint, an e-nose functionally occupies a niche between single-unit sensors,2 possessing good sensitivity, fast response, reasonable stability and low power consumption, and GC-MS devices with good sensitivity and selectivity, able to decompose complex gas-mixtures, still having high power consumption, high price and low portability.
However, the e-nose is required to be “trained” for the task of recognition of a smell or analyte prior to its real application, i.e. demanding to project analyte-related signals into an artificial space. At the same time, such techniques with very sophisticated apparatus as NMR or FTIR offer the possibility of selective determination without prior training because they rely on the intrinsic characteristics of molecules; molecular fingerprints modeled by the DFT can be further matched with the acquired real data.
Nevertheless, portable made-on-chip e-noses find huge attention due to a boost in artificial intelligence (AI) and machine learning (ML) which facilitates related R&D activities. Moreover, electronic noses are selective enough to distinguish within close homologs projected in artificial space. At the same time, the modern AI methods are powerful enough to predict the compound's chemical structure based on its chemical space coordinates34,35 by grouping chemical properties into high-dimensional virtual chemical space which is estimated to contain from 1012 to 10100 elements.36,37 Thus, we hypothesize that the implementation of ML methods enables the prediction of compound chemical structure based on e-nose-derived vector response towards analytes projected in artificial space coordinates. Specifically, matching chemical space built by AI processed data of chemical databases, e.g. database of molecular fingerprints, with e-nose built artificial space helps to design the ML model which predicts the structures of unknown compounds without a prior analyte mapping, i.e. e-nose training.
Metal oxides remain the most popular materials to be employed in e-noses due to their low price, easy-to-handle analytical signals, and rapid response time combined with good sensitivity.38–41 Aluminum-doped ZnO, or simply AZO, has demonstrated a remarkable sensitivity down to a sub-ppm range of analyte concentrations,42–45 stemming from its structural characteristics. Due to the small size of Al3+ ions compared to Zn2+, Al-doping induces chemical defects and increases the conductivity of the sensor.46,47 The sensing mechanism of AZO sensors belongs to the surface-controlled type where the gas sensitivity is determined by the number of surface adsorption sites.42 Al-doping increases the number of oxygen adsorption vacancies, which yields improved sensitivity. In 2019 Yoo, Günter et al. reported about the sensing properties of AZO sensors towards acetone detection in breath. AZO sensors were evaluated to have a response time of 3 s, and sensitivity of 23 ppm−1 at 10 ppm of acetone, including remarkably good selectivity versus other gases persistent in breath.48 Al-doped ZnO is usually obtained by sol–gel,49 hydrothermal50,51 and solvothermal52 methods, atomic layer deposition,53 reactive magnetron sputtering, pulsed laser deposition,42,54,55 chemical vapor deposition,56 and sintering.57 One of the most convenient methods of synthesis of oxide nanoparticles of complex chemical composition is the co-precipitation method.58 However, employing this method is often complicated by its reproducibility affecting the size and shape of the oxide nanoparticles. Recently, we introduced a programmed co-precipitation method for efficient control over the mentioned parameters.59,60 The co-precipitation method enables automatization of the protocols of synthesis of nanomaterials of various chemical compositions and substantially increases its speed.
Here, we study the synthesis and sensing performance of aluminum-doped zinc oxide towards different alcohols, homologs, and isomers in the mixture with air. We demonstrate the remarkable sensitivity of this material towards alcohol molecules with a limit of detection down to a few ppt. The selectivity of this sensor system is approached by using the multisensor concept helping to differentiate within close homologs and isomers (1- and 2-propanol and 1-butanol and isobutanol). We also demonstrate the possibility of analyte detection using a simple e-nose system even without prior training by matching the chemical space built using molecular fingerprints with artificial space built with e-nose data.
The synthesized AZO particles were separated by centrifugation, washed with distilled water, and then dried at 100 °C for 3 h. To facilitate crystallization we stabilized the obtained oxide powder at 350 °C for 1 h in air. We further prepared the dispersion of the obtained AZO nanoparticles using a mixture of ethanol with distilled water, v(C2H5OH)/v(H2O) = 1, under ultrasonication. The dispersion contained 5% of the AZO nanoparticles. The chips with the sensitive AZO layer were made by drop-casting 1 μl of the dispersion followed by stepwise drying at a temperature range of 25–100 °C. To fully remove residual solvents and stabilize the prepared layer we annealed the chip at 350 °C for 1 h in air. A schematic representation of chip preparation is given in the ESI (Note 1, Fig. S1†).
To examine the morphology of the AZO layer on a chip, we utilized scanning electron microscopy (SEM) in a secondary electron detector regime. The high-resolution SEM images of the selected areas at the representative chip were taken using FEI Teneo VolumeScope device (FEI Comp., the USA) at 20 kV.
The chemical composition of materials under study was confirmed by time-of-flight secondary ion mass spectrometry (ToF-SIMS) analysis coupled with a scanning electron microscopy unit (TOF-Sims, Tofwerk AG, Switzerland; Tescan Solaris, Tescan Orsay Holding, Czech Republic). We evaluated a chip area of 30 × 30 μm2 (or 35 × 35 μm2) between two Pt electrodes with the AZO material placed in-between. The material was bombarded by gallium ions employing a focused ion beam (FIB) source at an accelerating voltage of 20 kV and current 4 nA.
The ToF-SIMS data are acquired in positive ion mode due to the better sensitivity to Al and Zn.61 Mass resolution, m/Δm, was ca. 700. Secondary ions were registered using the ToF-SIMS detector (TOF-Sims C-TOF). The intensity of detection is evaluated by ion counts related to the ToF-SIMS extraction coefficient (device software built-in function, @ToF SIMS Explorer, Version 1.12.2.0), i.e. counts per extraction (cts/ToF extraction). The extraction corresponds to one pulse of the ToF, or, equivalently, one pixel in the FIB scan. Scan resolution equals ca. 70 nm (i.e. 512 pixels over 35 μm). The pulse length was 30 ns.
The structure of the AZO material was also studied with the help of transmission electron microscopy (TEM). For the TEM studies, we prepared samples by placing droplets of dispersion of AZO in isopropanol onto a lacey carbon film supported by a copper grid. Bright-field (BF) and dark field (DF) images, and selected area electron diffraction (SAED) patterns, were acquired with FEI Tecnai G2 F20 S transmission electron microscope (FEI Comp., The Netherlands). The ring patterns were analyzed using @CrysTBox ringGUI software.62
We calculated chemiresistive response, S, facilitated by the appearance of VOC in accordance with the relationship S = ΔR/Rair, where Rair is the resistance of the sensor segment in background air (MOhms) and ΔR represents the change in the resistance (MOhms) due to the appearance of VOC. Also, we estimated sensor response error accounting for fluctuations in the sensor segment resistance. The sensors' response and recovery time, t90, has been calculated as the time to reach 90% of the response starting from when the sensor is exposed to an analyte in the mixture with air, or the time to achieve 10% difference with the baseline when dry air is pulsed, respectively.
PCA is a linear dimension reduction technique based on the singular value decomposition of a feature matrix,64 which is a matrix of vectors that contain independent variables to be processed. The method transforms an array of possibly correlated variables into an array of linear non-correlated features, called principal components. It discards less important variables and preserves more valuable ones finding principal component axes along which the dispersion of data is high.65
To build a chemical space as a basis for our model we used molecular “fingerprints”, one of the most common representations of chemical structures. Those “fingerprints” are simplifications of the chemical information contained in any chemical entity through binary vectors. For this purpose (to codify the chemical structure), we utilized the PubChem Fingerprint database.66 The PubChem fingerprint encodes molecular fragment information with 881 binary digits. It is based on substructure analysis, i.e. analysis of the fragments of a chemical structure.67 A fingerprint is an ordered list of binary (1/0) bits. Each bit is a Boolean determination of, or test for, the presence of, for example, an element count, a type of ring system, atom pairing, atom environment (nearest neighbors), etc., in a chemical structure. We applied PCA to the “fingerprints” of selected analytes taken from the database.
Also, we have used PCA to build a space of the tested VOCs, homologs, and isomers, using a vector signal of 13 sensors acquired at 300 °C where each combination of sensor signals (resistance or response) gives a unique “fingerprint” for the particular analyte. Training data represented the recorded resistance transients of sensors in an array (or their response, S) when an analyte in the mixture with air is pulsed, while test data are obtained in a similar way, though, utilizing the data of another pulse.
We hypothesized that the chemical structure is correlated with the sensors' response. To construct a bridge between chosen PubChem “fingerprints” of VOCs projected to space made by PC components and PCA results of e-nose signal processing, i.e. an artificial space built from sensors' array responses, we employed the DT supervised non-parametric learning method. We utilized DecisionTreeRegressor from the Scikit-learn68 Python package with default parameters. k-Fold cross-validation is applied to estimate the performance of the model employing the data which was not used for the training, namely, we trained a regression model to match and relate chemical “fingerprints” based on a molecular structure (PubChem) to sensors array “fingerprints” (vector response) for chosen analytes.
While the space of PubChem “fingerprints” is too large, the number of points is rather small (n = 8) to train our model. To overcome this issue, we reduced the dimension of the PubChem fingerprint vectors from 881 to dimension of 2 using PCA and sensor array data, i.e. vector of responses of 13 sensors, to dimension of 1, further referred to as “reduced sensor data”. We found the DT model suitable for such a small dataset, i.e. to prove the proposed concept (for parameters see the ESI, Note 3†).
Fig. 1 XRD pattern and corresponding refinement by Rietveld method data for the synthesized ZnO – 1.5% Al2O3 powder. |
The material obtained by the method of controlled co-precipitation, placed on a chip, is represented by nearly round-shaped nanoflakes with a mean width of 0.5 μm (Fig. 2a). We have also identified agglomerated particles whose close inspection evidences the highly porous structure (see the ESI, Fig. S4a†). ToF-SIMS mapping has been conducted to evaluate the spatial distribution of Zn and Al over the AZO layer placed on the chip. The ToF-SIMS maps for Al and Zn, 35 × 35 μm2, are presented in Fig. 2b and c. While ToF-SIMS is considered to be a very surface sensitive (1–2 monolayers of sampling depth) technique,69 the maps indicate even distribution of Zn and Al elements that supports the homogeneous composition of AZO flakes and agglomerates obtained by the programmed co-precipitation method. The positive mass spectrum for Zn and Al is presented in the ESI (Fig. S5†). The results of TEM studies corroborate with SEM data suggesting the material to be crystallized in the form of round plates with a width of up to 400–600 nm (Fig. 2d). The flakes are composed of interconnected crystallites forming a rather porous structure (Fig. 2e and S4b in the ESI†). The crystallite size is about 20 nm proved by DF TEM results given in the ESI, Fig. S4c.† The acquired ring pattern indicates the ZnO crystal phase, space group P63mc (a = b = 3.251 Å, c = 5.207 Å, α = β = 90°, γ = 120°), as depicted in Fig. 2f. The phase is identified by (100), (002), (102), (110), (200), and (203) planes characterized by 2.80, 2.58, 2.00, 1.65, 1.40 and 1.09 Å d-spaces, respectively (JCPDF #75-0576).
A change in analyte concentration in air facilitates a corresponding change in resistance (Fig. 3b) demonstrated for the representative sensor at the chip heated to 300 °C. The results suggest a nonlinear dependence of the sensor's electrical properties on concentration with an obvious trend to saturation at high concentrations of the analyte in air, typical for semiconductor oxides due to a limited number of active surface sites (see the ESI, Fig. S6† for all on-chip sensors' resistance transients). Fig. 3c shows the concentration dependence of the sensor recorded at 200, 250, and 300 °C. While the best performance is achieved at 300 °C, the change to lower temperatures is accompanied by an increase of resistance, possessing smaller changes of the sensor resistance under adsorption of the analyte. We also notice longer response and recovery times in the results recorded at 200 °C. Mean response and recovery times, t90, for the presented sensor upon the appearance of 1-propanol, are correspondingly 28 and 173 s, 43 and 173 s, 98 and 167 s at 300 °C, 250 °C, and 200 °C. We have further employed this sensor to demonstrate the stability of the sensing performance of the AZO material. Stability tests have been handled in 3 months after acquiring isotherms presented in Fig. 3b and c. We have checked the properties of the sensor by the repetitive pulsing of 1.1 ppm of 1-propanol mixed with dry air followed by dry air pulses (Fig. 3d). We notice that the absolute resistance of the sensor has changed slightly over the time of storage. However, despite the differences in absolute resistance value, the sensitivity (change in resistance normalized by resistance in the air) remains the same and the sensor demonstrates a highly stable reproducible signal. In Fig. 3e one finds three representative isotherms (200, 250, and 300 °C) for 1-propanol mixed with air in a range of concentrations, 0.01–1.10 ppm, calculated using the data presented in Fig. 3c. The temperature decay yields a decrease of sensitivity, emphasizing the best operating temperature to be 300 °C.
The chemiresistive response has been carefully investigated for all eight analytes. In Fig. 3f–m we present isotherms for eight analytes in the mixture with air used in this study at 300 °C. Interestingly, for the analytes with greater molecular mass, like butanol, isobutanol, and isoamyl alcohol, saturation is achieved at lower concentrations. At the same time, the sensor demonstrates a weaker response to the analytes with lower molecular mass like methanol and ethanol. We calculated the limit of detection, LoD, as the triple amplitude of signal noise.70 The median LoD values belong mainly to the region of concentrations in ppb or even ppt domain, e.g. 50 ppt for isobutanol and 150 ppt for 1-propanol at 300 °C. Using the Freundlich isotherm, S = kCn, where C is the concentration, we fitted the obtained isotherms to further estimate n values which vary from 0.17 to 0.36 for the analytes at 300 °C which confirms non-linear response characteristics typical of semiconductor oxide sensors.31 The mean response and recovery times, along with median sensor response calculated for 0.94 ± 0.05 ppm of analyte mixed with air, the median value of power in S = kCn, and median LoD at 300 °C are given in Table 1.
Acetone | 2-Propanol | Ethanol | Methanol | Isobutanol | 1-Propanol | Isoamyl alcohol | 1-Butanol | |
---|---|---|---|---|---|---|---|---|
Median LoD, ppb | 1.91 | 1.43 | 1.96 | 36.12 | 0.05 | 0.15 | 2.49 | 1.21 |
Mean t90 (response), s | 69 ± 2 | 33 ± 2 | 36 ± 2 | 54 ± 2 | 20 ± 2 | 28 ± 2 | 43 ± 2 | 15 ± 2 |
Mean t90 (recovery), s | 155 ± 12 | 162 ± 12 | 103 ± 12 | 113 ± 7 | 186 ± 12 | 173 ± 12 | 258 ± 12 | 333 ± 12 |
Median S (0.94 ± 0.05 ppm) | 0.595 | 0.508 | 0.531 | 0.434 | 0.761 | 0.789 | 0.681 | 0.860 |
Median n (S = kCn) | 0.197 | 0.246 | 0.293 | 0.357 | 0.169 | 0.197 | 0.253 | 0.174 |
Both chemoresistive responses and sensitivity coefficients for an array of sensors represent a unique combination, i.e. fingerprint, that favors using the pattern recognition algorithms to handle the data and projecting it to artificial space to meet selective discrimination of the analytes. Usually, selective classification of analytes is approached by using dimension reduction methods or ML algorithms employing train and test datasets, or cross-validation routine. Applying the PCA to project vector responses of 8 studied analytes using acquired responses of an array of 13 sensors at 300 °C, reduced to the analyte concentration of 0.94 ± 0.05 ppm in the mixture with air, enables their spatial separation in the space of two principal components (Fig. 4i). The PCA is performed for the data obtained for concentrations of vapors close to unity, which helps to mitigate concentration dependence targeting the primary task of selective discrimination of an analyte. The concentration of the particular analyte can be evaluated after its selective discrimination using one calibrated sensor. PCA featuring the responses normalized to concentration dependence (Cn) is given in the ESI, Fig. S7.† Notably, a recent study approaches this issue by using a multi-task convolutional neural network78 which enables us to obtain the concentration value, type of analyte, and device status. There is a good separation of projected vector responses of the studied analytes, confirming their selective identification. Some data tend to position rather closely in 2D PC space related to the structural similarity of the analyte molecules (Fig. 4i). The studied n-alcohols, i.e. methanol, ethanol, 1-propanol, and butanol, are projected mostly along the first PC component, meaning that most information that helps to differentiate these analytes is described by this component, but the similarity is supported by a small contribution of the second one. The results of PCA data reduction for molecular substructure features of analytes' “fingerprints” taken from the PubChem database are presented in Fig. 4j. The later data show that almost all alcohol molecule-related clusters are positioned along the second PC component, i.e. favoring its spatial separation, with a clear trend for n-chain alcohol molecules. Notably, the 2-propanol related cluster is projected close to ethanol and 1-propanol, hinting at the similarities of these alcohols; accordingly, isobutanol is projected close to n-butanol.
Furthermore, to evaluate the possibility of analyte selective detection without prior training of the e-nose, we used the ML method, DT, to relate reduced sensor data and results of PCA of molecular “fingerprints”. Training a full model to predict sensor response from PubChem “fingerprints” (or, to predict molecular “fingerprint” from sensor data, which would be even better from a practical standpoint) is rather complicated due to the small number of data points, but not the principal impossibility. We further demonstrate the principle feasibility of this approach by reducing data dimensionality.
We fitted (trained) DecisionTreeRegressor for each analyte on 7 other molecular PubChem “fingerprints” projected into 2D space via PCA and reduced sensor data projected into 1D space via PCA (Fig. 4k) and tried to predict that the reduced sensor data for the 8th analyte which was not used for fitting, i.e. corresponded to an unknown analyte. This operation was performed for all studied analytes. The results indicate how successfully analytes are predicted, showing a good match between sensor data for the analyte (point), and predicted value (cross). 2-Propanol, isobutanol, and 1-propanol molecules seem to have the best prediction accuracy. Training the DecisionTreeRegressor with a leave-one-out cross-validation strategy enables us to obtain the R2 value for the prediction to be 0.69, where R2 denotes the coefficient of determination. The current results suggest that the best prediction is for 1-propanol for 1D PCA results indicating closer Euclidean distances to the predicted point. Given the information presented in the figures, such a value suggests a good opportunity to predict the analyte of interest using the proposed approach. We have also evaluated Mol2vec “fingerprints” for the determination of alcohols and other VOCs using other chips prepared by a similar method, see the ESI (Note 6, Fig. S8†).79,80
Detection of close homologs or even isomers is complicated by the type of interaction of the molecule with the surface, i.e. shift of Fermi level, or catalytic process with an injection of charge carriers as in the case of Co oxide.81,82 A particular response is defined by several parameters of the material, its receptor or transduction functions, which stem from surface states, crystal size, type of activation, etc.83,84 It makes the response of intrinsically cross-sensitive oxides an outcome of many different material-related input parameters. Although there is a direct dependence on the molecular mass of n-homologs of alcohols as shown in the work of Fedorov et al.,77 in the case of isomers it might be complicated by the way the molecule is adsorbed on the surface, i.e. deviating from this direct trend. Thus, we expect no strong linear dependence of response value on molecular mass when branched isomers are tested compared to n-alcohols. A particular configuration or orientation of the isomer molecule near the oxide surface might be very similar to the orientation of some n-alcohols on the surface, i.e. the way the isomer molecule approaches the surface might originate some overlapping of “fingerprints” of sensor responses in artificial space that explains the obtained prediction accuracy. Surely, one might improve it by obtaining a larger database of sensor array vector signals, i.e. testing a greater number of various analytes. Still, here we have shown, for the first time, that using a miniature e-nose based on simple resistive cross-sensitive oxide sensors might allow approaching selective recognition of the analytes' close homologs and isomers even without prior training, but just with the support of ML employed for connecting the chemical “fingerprint” databases with sensor vector data projected in artificial space.
We show a remarkable, up to 0.87, chemoresistive response of AZO sensors at the e-nose to alcohol vapors, 0.9 ppm, in the air at 300 °C with a detection limit down to sub-ppb and even ppt level. The sensors indicate good stability of response and low response time. We have confirmed a direct dependence of chemiresistive response on analyte molecular weight for n-alcohols, disrupted in the case of isomers.
By using PCA analysis and the Decision Tree ML method, we demonstrate not only the selective recognition of close alcohol homologs and alcohol isomers but also the feasibility of their detection without prior e-nose “training” just by matching available molecular “fingerprints” with e-nose analyte-related vector responses.
Footnote |
† Electronic supplementary information (ESI) available. See DOI: 10.1039/d1ta10589b |
This journal is © The Royal Society of Chemistry 2022 |