Open Access Article
This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence
Correction: Quantifying nanotherapeutic penetration using a hydrogel-based microsystem as a new 3D in vitro platform
Saba
Goodarzi
a,
Audrey
Prunet
a,
Fabien
Rossetti
a,
Guillaume
Bort
a,
Olivier
Tillement
a,
Erika
Porcel
b,
Sandrine
Lacombe
b,
Ting-Di
Wu
cd,
Jean-Luc
Guerquin-Kern
cd,
Hélène
Delanoë-Ayari
a,
François
Lux
ae and
Charlotte
Rivière
*ae
aUniversity of Lyon, Université Claude Bernard Lyon 1, CNRS, Institut Lumière Matière, F-69622, Villeurbanne, France. E-mail: charlotte.riviere@univ-lyon1.fr
bUniversité Paris-Saclay, CNRS, Institut des Sciences Moléculaires d'Orsay, 91405, Orsay, France
cInstitut Curie, Université PSL, Paris, France
dUniversité Paris-Saclay, CNRS, Inserm, Centre d'Imagerie Multimodale, 91401, Orsay, France
eInstitut Universitaire de France (IUF), France
First published on 17th December 2021
Abstract
Correction for ‘Quantifying nanotherapeutic penetration using a hydrogel-based microsystem as a new 3D in vitro platform’ by Saba Goodarzi et al., Lab Chip, 2021, 21, 2495–2510, DOI: 10.1039/D1LC00192B.
In Fig. 2E the legend of the graph should be inversed. The corrected legend is: white bars#2D, black bars#3D. The corrected figure is shown below.
 | ||
| Fig. 2 Quantification of penetration and cellular uptake of AGuIX®-Cy5.5 nanoparticles in HCT-116 tumour spheroids and monolayer cell culture. (A) Representative confocal fluorescence images of HCT-116 spheroids incubated with 0.8, 1.5 and 2 mM concentration of AGuIX®-Cy5.5 for 24 h for four different depths (0, 30, 60 and 90 μm). (B) Mean intensity along with standard deviation (light colors) of AGuIX®-Cy5.5 as a function of the distance from the spheroid periphery (see the orthogonal view in the inset, green = nuclei, red = AGuIX®-Cy5.5) for 0.8 mM (yellow, N = 73), 1.5 mM (green, N = 68) and 2 mM (red, N = 121); three independent experiments. (C) Representative confocal fluorescence images of monolayer HCT-116 cells exposed to AGuIX®-Cy5.5 nanoparticles with 0.8, 1.5 and 2 mM concentration. (D) Quantification of the mean intensity of AGuIX®-Cy5.5 nanoparticles in maximal projection of confocal fluorescence images of monolayer cells after 24 h of incubation with different AGuIX®-Cy5.5 concentrations: 0.8 mM (yellow, N = 40), 1.5 mM (green, N = 40) and 2 mM (red, N = 40); three independent experiments. Error bars represent the standard deviations. (E) Mean and standard deviation of the concentration of Gd (ppb μm−3) uptaken by the cells after incubation with 0.8, 1.5 and 2 mM concentration of AGuIX® for 24 h in HCT-116 cell spheroids and monolayer cell culture measured with ICP-MS (N = 6, two independent experiments). | ||
The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
| This journal is © The Royal Society of Chemistry 2022 |