Enzyme-responsive hybrid prodrug of nitric oxide and hydrogen sulfide for heart failure therapy

Qi Liu; Guangbo Ji; Yushu Chu; Tian Hao; Meng Qian; Qiang Zhao

doi:10.1039/D2CC02267B

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Enzyme-responsive hybrid prodrug of nitric oxide and hydrogen sulfide for heart failure therapy†

Qi Liu,‡^a Guangbo Ji,‡^a Yushu Chu,^a Tian Hao,^a Meng Qian*^a and Qiang Zhao

*^a

Author affiliations

* Corresponding authors

^a State key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Sustainable Chemical Transformations, Key Laboratory of Bioactive Materials (Ministry of Education), Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300071, China
E-mail: qiangzhao@nankai.edu.cn, 13821705466@163.com

Abstract

A hybrid prodrug was synthesized to realize the combined delivery of nitric oxide and hydrogen sulfide. The NO–H₂S donor can release nitric oxide and hydrogen sulfide step by step in response to the endogenous enzymes β-galactosidase and carbonic anhydrase, providing potent therapeutic efficacy for heart failure post- myocardial infarction.

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Article information

DOI: https://doi.org/10.1039/D2CC02267B
Article type: Communication
Submitted: 21 Apr 2022
Accepted: 05 Jun 2022
First published: 06 Jun 2022

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Chem. Commun., 2022,58, 7396-7399

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Enzyme-responsive hybrid prodrug of nitric oxide and hydrogen sulfide for heart failure therapy

Q. Liu, G. Ji, Y. Chu, T. Hao, M. Qian and Q. Zhao, Chem. Commun., 2022, 58, 7396 DOI: 10.1039/D2CC02267B

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Chemical Communications

Enzyme-responsive hybrid prodrug of nitric oxide and hydrogen sulfide for heart failure therapy†

Abstract

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Enzyme-responsive hybrid prodrug of nitric oxide and hydrogen sulfide for heart failure therapy

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