Dipanjan
Mandal
* and
David
Quigley
Department of Physics, University of Warwick, Coventry CV4 7AL, UK. E-mail: dipanjan.mandal@warwick.ac.uk; d.quigley@warwick.ac.uk
First published on 13th September 2021
Nucleation phenomena are ubiquitous in nature and the presence of impurities in every real and experimental system is unavoidable. Yet numerical studies of nucleation are nearly always conducted for entirely pure systems. We have studied the behaviour of the droplet free energy in two dimensional Ising model in the presence of randomly positioned static and dynamic impurities. We have shown that both the free energy barrier height and critical nucleus size monotonically decreases with increasing the impurity density for the static case. We have compared the nucleation rates obtained from the Classical Nucleation Theory and the Forward Flux Sampling method for different densities of the static impurities. The results show good agreement. In the case of dynamic impurities, we observe preferential occupancy of the impurities at the boundary positions of the nucleus when the temperature is low. This further boosts enhancement of the nucleation rate due to lowering of the effective interfacial free energy.
Modelling nucleation from solution is an active area of research with relevance to pharmaceutical manufacture, biomineral formation and other highly complex precipitation processes. Atomistic simulations12 are now able to make quantitative predictions of the nucleation rate. Unfortunately, even for nucleation of simple salt crystals from solution13,14 agreement with experiment remains elusive and sensitive to details of the atomistic force field and the order parameter used to identify solid regions in the simulation.15 In addition, the solution is nearly always simulated as pure with no impurities or spectator/counter ions. A quantitative understanding of how these additional species impact on the nucleation rate is lacking.
The most basic physics of nucleation from solution can be captured using a simple lattice-based model of solute precipitation.16 Minimal models of this kind in two and three dimensions have been used to probe assumptions of CNT and to test advanced methods for quantifying rare events against well-established results.17–21 Extensions of the basic Ising-like model have been used to study nucleation inside a rectangular pore,22,23 on substrates,24 two-step nucleation mechanisms,25 and nucleation in the presence of shear9 and on single immobile microscopic impurities.26 Studies have also explored the choice of microscopic kinetics on the nucleation rate.27 In this work we study such a model in the presence of neutral impurities as a further step toward introducing some of the complexity found in “real” solutions. We explore how this changes nucleation rate, critical nucleus size and free energy barrier height, as a function of impurity concentration.
We consider two scenarios, static and dynamic impurities. In the static impurity case the impurities are sites distributed randomly in space and fixed throughout the simulation. We work with quantities averaged over many samples of this static disorder. In the dynamic case impurities can migrate via Kawasaki dynamics.28 A particular advantage of working with such simplified models is that the timescale of impurity migration relative to cluster growth can be adjusted to probe different kinetic regimes.
We have used umbrella sampling techniques to calculate the free energy barrier for different densities of the impurity sites. We also calculate the nucleation rate using the Forward flux sampling (FFS) technique and compare the results to those computed from the free energy barrier via the Becker–Döring expression. We have shown that the impurity particles preferentially occupy the boundary positions of the nucleus for the dynamic case when the temperature is low. This surface accumulation process enhances the nucleation rate by a multiple of 104 compared to the static case.
The rest of this paper is organised as follows. In Section 2, we describe the model and simulation techniques used to study the model. Variation of the free energy barrier height and the critical nucleus size are shown in Section 3. Section 4 contains the comparison of theoretical and computational nucleation rates for different impurity concentration. The effect of dynamic impurities on barrier height as well as nucleation rates are described in Section 5. Finally we conclude in Section 6.
![]() | (1) |
We study the discontinuous magnetisation reversal for a system with initially negative magnetisation in the presence of a positive magnetic field. This necessarily occurs only for temperatures T < Tc (Tc is the critical temperature) and proceeds via nucleation and growth of domains with positive magnetisation. In the lattice-gas (solute precipitation) analogy this corresponds to an initially mostly-empty lattice (solvent-rich) to a full lattice (solute-rich) at a chemical potential where equilibrium with a particle reservoir corresponds to a mostly-occupied lattice.
We modify the model by introducing a third spin state Si = 0 at random positions of the lattice. This represents non-magnetic impurities, or “neutral” impurity ions in solution which do not favour interaction with either solute or solvent neighbours. The interaction energy of impurity particles with both solute and solvent is chosen to be half way between solute–solvent and solute–solute (or solvent–solvent) interaction energy, i.e. zero. Other possibilities could be studied by creating impurities which interact more favourably with solvent than solute (for example). In the present work we restrict ourselves to the neutral case. These non-zero spins are evolved in time via the usual spin–flip dynamics in which a randomly selected spin is flipped, and the move accepted or rejected according to the Metropolis criterion. In what follows we mainly use the magnetic terminology for brevity.
The overall density of spin-0 impurities is kept fixed throughout the simulation. Further, we consider two different circumstances, static and dynamic impurities. In the static case, the impurity particles are immobile. In the dynamic case impurities can diffuse through the lattice using spin-exchange dynamics often known as Kawasaki dynamics.28 The ratio of impurity-diffusion move attempts to spin flip move attempts controls the mobility of impurities relative to the nucleation timescale.
We calculate the nucleation rate using two independent methods, and as a function of the impurity density. The first method calculates the free energy barrier to nucleation and applies the BD expression for the nucleation rate and the second method is the Forward Flux Sampling (FFS) method which calculates the rate independently of classical nucleation theory. A typical configuration of the system during the transition is shown in Fig. 1 where red represents occupied (Si = 1) sites, blue represents impurity (Si = 0) and white represents empty sites (Si = −1).
In the next sections, we describe in more detail the simulation techniques used to calculate the barrier heights and the nucleation rates.
The relative free energy for a droplet of size λ at the n-th window may be written as
fUSn(λ) = −kBT![]() | (2) |
![]() | (3) |
FUSn(λ) = fUSn(λ) + Sn. | (4) |
The nucleation rate is then estimated as
![]() | (5) |
In our simulations, we have used 250 interfaces with a constant gap of 10 between adjacent interfaces. The position of the first interface varies for different temperatures. For T = 1.5 and h = 0.05, the first interface position is λ0 = 16. The position of first interface is chosen such that crossings are infrequent, i.e. the probability of being at λ = λ0 state is quite low (λ0 is above the 95th percentile of the cluster probability in the parent phase). We run trials starting from the metastable (negative spin) phase to calculate the initial positive flux, storing configurations which cross λ0 in the direction of increasing λ. We then initialise Monte Carlo trajectories from randomly chosen configurations at this interface and count how many reach λ1 before returning to λA to obtain the crossing probability of the first interface. This is repeated for all subsequent interface pairs. In each case we sample the interface until 25200 successful events are captured. The initial flux is calculated based on how much time is needed to produce 25
200 positive crossings of λ0. In a typical FFS simulation we sample interface up to λ ∼ 2500. Plots of the interface probabilities at λ = λi and the rate of reaching state λ starting from the metastable phase for different impurity densities ρi are shown in Fig. 2(a) and (b) respectively for fixed T = 1.5 and h = 0.05. The interface probability and rate saturate for large λ indicating post-critical behaviour. The saturation becomes slower with increasing ρi.
The free energy of a cluster of +1 spins of size λ may be written as
![]() | (6) |
![]() | (7) |
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Fig. 3 Plot of the free energy FUS(λ,ρi) obtained from the US simulations as a function of the nucleus size λ for different static impurity densities ρi at T = 1.5 and h = 0.05. The black line is the fit to the modified CNT expression of the free energy F(λ,ρi) (see eqn (9)). The error-bars are less than point size. |
To gain insight into this enhancement, we fit our free energy barriers to nucleation theory and extract trends in the resulting physical parameters. In a previous study Ryu and Cai18 have numerically calculated free energy barriers in the absence of impurities and confirmed these accurately obey a cluster free energy given by
![]() | (8) |
![]() | (9) |
A3(ρi) = −kBT![]() ![]() | (10) |
In the presence of impurities we fix for all ρi. Allowing this parameter to vary has negligible impact on the quality of fit suggesting that the low impurity densities we study here do not significantly alter fluctuations in cluster shape.
The size-independent term A3(ρi) is obtained from the density of isolated +1 spins during unbiased simulations of the system in the metastable phase. This varies with impurity concentration. The only free parameter when fitting the free energy plots in Fig. 3 for different ρi is the interfacial tension per unit length A1(ρi). As shown in Fig. 4(a), this decreases linearly with increasing impurity density for fixed T and hence can be written as
A1(ρi) = m1ρi + m2. | (11) |
Spin-0 impurities which bridge between sites occupied by opposite spins lower the overall energy of the system by a greater amount than impurities surrounded entirely by spins of the same sign. Hence it is the presence of spin-0 impurities at the cluster boundary (rather than inside the cluster) which has the greatest impact on the nucleation barrier. With static impurities, the average impurity density per unit length of cluster circumference is independent of both temperature and cluster size, and hence we can capture their impact on the interfacial free energy via this simple functional form.
Now we compare the critical nucleus size and the barrier height obtained from our modified free energy expression and from the simulation. From eqn (8) it is easy to show that the critical nucleus size may be written as
![]() | (12) |
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Fig. 5 Variation of (a) the critical nucleus size λc and (b) the maximum free energy barrier F(λc,ρi) as a function of ρi for T = 1.5 and h = 0.05. |
![]() | (13) |
![]() | (14) |
The quantity Dc is extracted from the mean squared variation in the nucleus size as plotted in Fig. 6(a) with increasing time for different impurities densities. We perform separate Monte Carlo simulations to calculate Dc for different ρi. The initial configuration at t = 0 is taken to be the nucleus with critical size. The mean squared variation is defined as
Δλ2(t) = [λ(t) − λc]2. | (15) |
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Fig. 6 Variation of 〈Δλ2(t)〉 as a function of time t with (a) static impurities for different densities and (b) dynamic impurities for different α. |
We average Δλ2(t) over an ensemble of 105 such trajectories for each line plotted in Fig. 6(a). The diffusion coefficient Dc is defined as
![]() | (16) |
The nucleation rates obtained from the FFS [see eqn (5)] and BD theory [see eqn (13)] are compared in Fig. 7 which shows good agreement. From this we conclude that the impact of static impurities on nucleation rate is well described via classical nucleation theory with only minor extensions required to capture trends with increasing impurity density over the range explored 0 ≤ ρi ≤ 0.028. For higher impurity densities we observe multiple overlapping pre-critical nuclei and therefore CNT is not appropriate.
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Fig. 7 Comparison of the nucleation rates obtained from the FFS method and the Becker–Döoring theory for T = 1.5 and T = 1.4 with h = 0.05. |
We have plotted the nucleation rate I(MCSS−1) as a function of ρi for different T with fixed h = 0.05 in Fig. 8(a). The nucleation rate grows exponentially with increasing impurity density and the exponential growth becomes faster with decreasing temperature. The slope of the best fitted line increases with decreasing T for fixed h as shown in Fig. 8(a). This indicates that the barrier height decreases more rapidly with increasing ρi when the temperature is lowered. The variation of nucleation rates for different h with fixed T = 1.5 is shown in Fig. 8(b). The rates grow exponentially as a function of ρi for fixed T and become more steeper with decreasing h. We can approximately write the nucleation rate as I ≈ Cexp(νTρi) and I ≈ C
exp(νhρi) for fixed h and T respectively. Both νT and νh increase monotonically with decreasing T and h.
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Fig. 8 Variation of the nucleation rate as a function of ρi for different values of the temperatures with fixed external field h = 0.05. |
(1) Low mobility impurities: the boundary of the growing +1 spin cluster will expand rapidly compared to the randomly distributed and slow-moving impurities, resulting in a reduction of the interfacial free energy similar to the static case.
(2) High mobility impurities: sufficiently fast-moving impurities can reach a local equilibrium distribution much faster than the +1 spin nucleus can grow or shrink. This implies that a description of the nucleation process in terms of a free energy at each nucleus size remains appropriate.
Here we apply both the BD and FFS approaches in the high mobility regime and compare to the static regime studied above.
We consider dynamic impurities of fixed density ρi. Impurity sites may move to the one of the four neighbouring sites via Kawasaki dynamics. The spin 0 impurity (blue) may exchange with a spin +1 (red) or spin −1 (white) neighbouring sites. We do not consider spin exchange dynamics involving only red and white sites. We define the quantity α such that the mobility of impurity particles increases with increasing α. The mobility parameter α takes values between 0 to 1. In our Monte Carlo simulations we attempt a spin exchange move for a random impurity particle with probability α. Attempts to flip the spin of randomly chosen size with spin ±1 are attempted with probability 1 − α.
Rates are reported to be consistent with the previous section, i.e., based on a unit of time during which, on average, every site on the lattice is subjected to one trial flip. Hence for large α, many Kawasaki exchange moves involving impurities are attempted per time unit.
We have plotted the free energy barrier to nucleation both for static (α = 0) and high mobility (α = 0.95) impurities with density ρi = 0.020 for different values of α. The free energy plots for T = 1.0 and T = 1.5 are shown in Fig. 9(a) and (b) respectively. We observe that the barrier height decreases significantly for the nonzero value of α compared to the α = 0 case when the temperature is low (T = 1.0). However, the critical nucleus size is approximately the same. By contrast, we see that the barrier height and critical nucleus size of the free energy do not change as dramatically between α = 0 and α = 0.95 at the higher temperature T = 1.5.
Nucleation rates I as a function of ρi obtained using FFS for static and high mobility impurities at T = 1.5 and h = 0.05 are shown in Fig. 10. We see that the rates obtained using FFS for different α are similar (i.e. within one order of magnitude) for every ρi at this high temperature, but there is an indication of high mobility impurities increasing the nucleation rate. This is consistent with the observation of marginally lower barrier heights for high α at T = 1.5 in Fig. 9(b).
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Fig. 10 Comparison of nucleation rates obtained via FFS for static (α = 0) and high mobility (α = 0.95) impurities. |
Based on the free energies in Fig. 9(a), we expect a much more dramatic impact of high mobility impurities at the lower temperature of T = 1.0. The FFS method becomes extremely inefficient at this temperature due to a very low density of spin +1 sites in the metastable phase. Computing a sufficiently accurate flux through λ0 is intractable in this case.
We have, however, calculated the nucleation rate at T = 1.0 using the Becker–Döring expression. The rates are 4.005 × 10−38 MCSS−1 and 2.180 × 10−34 MCSS−1 for α = 0 and α = 0.95 respectively. The mobility of impurities hence enhances the nucleation rate by several orders of magnitude. The mean squared deviation 〈Δλ2(t)〉 for dynamic impurities with different α at T = 1.0 is shown in Fig. 6(b). We see that the slope of the plot reduces for α ≠ 0 implying the reduction of diffusion coefficient Dc for dynamic impurities.
The BD rates at T = 1.5 are 1.128 × 10−15 MCSS−1 and 1.930 × 10−15 MCSS−1 for α = 0.95 and α = 0.0 respectively. The corresponding critical cluster sizes are λc = 368 and λc = 363 for dynamic and static case respectively.
The role of high mobility impurities at high versus low temperature for three different temperatures with fixed h = 0.05 is illustrated in Fig. 11(a–f). Fig. 11(a, b), (c, d) and (e, f) are the snapshots of typical configuration after equilibrium at T = 1.5, T = 1.0 and T = 0.9 respectively for both static and dynamic impurities. For the purposes of this illustration we set the mobility parameter α = 0.95 prioritising the spin exchange dynamics for the impurity particles. Initially the impurities are placed randomly on the lattice. We create a circular nucleus of red (spin +1) particles at the centre of the lattice of size λ = 600 and evolve the system such that the cluster size remain confined within a range [λ − 10, λ + 10]. We see that the impurity particles preferentially occupy the boundary positions of the nucleus at low temperatures. This happens because the particular impurity particles modelled here act as a surfactant, reducing the surface free energy. However, at high temperatures the phenomenon of preferential occupancy of the blue particles at the boundary positions is entropically unfavourable leading to a less dramatic enhancement of the nucleation rate.
To quantify this observation, we plot the equilibrium fraction ϕ of the impurity particles present at the boundary of a static nucleus as a function of T for different sizes of the nucleus as shown in Fig. 12. The quantity ϕ is defined as
![]() | (17) |
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Fig. 12 Fraction of the blue particles present at the boundary of the nucleus with increasing the temperature for different size of the initial nucleus λi. |
We have not explored the regime of intermediate impurity mobility. Here one would not expect the distribution of impurities to equilibrium on a timescale more rapid than that on which spin +1 cluster grow or shrink. This would invalidate a free-energy based description, but could be amenable to a description based on BD theory if growth/shrinkage rates could be evaluated directly. Rates in this regime can possibly be probed via FFS, however in the high temperature regime accessible to this method we expect little impact of mobility on nucleation rate due to the less-dramatic difference between the two limiting cases of zero and high mobility.
We stress that our study has only considered the case where the impurities interact with both spin up and spin down sites in the same way. Different behaviour would be expected if (for example) the interactions favoured location of impurities within the bulk of the metastable phase. Future work will attempt to map behaviour in different interaction regimes such that approximate connections to solute precipitation can be made.
The study of the nucleation in the presence of random impurities on triangular lattice and three dimensional cubic lattice is an open area for future research. It would be interesting to investigate how the different dynamics of the impurity particles in other lattice geometries impact the nucleation rate.
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