Biphasic nucleophilic aromatic substitution using a microreactor under droplet formation conditions

Abstract

The biphasic nucleophilic aromatic substitution of 4-fluoronitrobenzene was carried out using a microreactor. To realize an efficient reaction process, we performed microflow reactions under droplet formation conditions to give the substituted products in excellent yields. The solvent effect was also investigated, and it was found that the use of diisobutyl ketone as an organic phase greatly accelerated the reaction.