Fatemeh Mohammadsaleh*a,
Maryam Dehdashti Jahromib,
Abdol Reza Hajipour
cd,
Seyed Mostafa Hosseinic and
Khodabakhsh Niknam
*a
aDepartment of Chemistry, Faculty of Nano and Bio Science and Technology, Persian Gulf University, Bushehr, Iran. E-mail: f.mohammadsaleh@gmail.com; niknam@pgu.ac.ir
bFaculty of Engineering, Jahrom University, Jahrom, Iran
cPharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, Islamic Republic of Iran
dDepartment of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532 WI, USA
First published on 11th June 2021
1,2,3-Triazole is an interesting N-heterocyclic framework which can act as both a hydrogen bond donor and metal chelator. In the present study, C–H hydrogen bonding of the 1,2,3-triazole ring was surveyed theoretically and the results showed a good agreement with the experimental observations. The click-modified magnetic nanocatalyst Pd@click-Fe3O4/chitosan was successfully prepared, in which the triazole moiety plays a dual role as both a strong linker and an excellent ligand and immobilizes the palladium species in the catalyst matrix. This nanostructure was well characterized and found to be an efficient catalyst for the CO gas-free formylation of aryl halides using formic acid (HCOOH) as the most convenient, inexpensive and environmentally friendly CO source. Here, the aryl halides are selectively converted to the corresponding aromatic aldehydes under mild reaction conditions and low Pd loading. The activity of this catalyst was also excellent in the Suzuki cross-coupling reaction of various aryl halides with phenylboronic acids in EtOH/H2O (1:
1) at room temperature. In addition, this catalyst was stable in the reaction media and could be magnetically separated and recovered several times.
Academic and industrial discoveries of efficient and selective catalysts for a wide variety of organic reactions have had a huge influence on minimizing the costs of manufacturing and waste disposal.3 Heterogenization of homogeneous catalysts on solid supports has received significant attention in the catalysis researches and follows the majority of the principles of the green chemistry framework in synthesis routes in terms of the separation and catalyst-recycling.4,5 Therefore, the design and development of a suitable support as catalyst carrier capable of improving the catalyst characteristics, especially for metal-based catalysts, by a cooperative effect between the metal complex and the support, is still an important challenge for successful catalysts.6
Chemistry is knowledge of wonders, and in the depths of this science, marvelous mysteries can be discovered. 1,2,3-Triazoles are interesting class of N-heterocyclic compounds, which are typically prepared by Cu(I)-catalyzed azide–alkyne 1,3-dipolar cycloaddition (CuAAC) reaction recognized as a highly important example of “click chemistry”.7,8 1,2,3-Triazole produced in the click reaction offers properties beyond just the sum of its components, the azide and alkyne. It has shown various successful applications in different domains such as anion recognition,9–11 catalysis.12,13 surface modification and material science.14,15 This nitrogen-rich aromatic entity has a great dipole moment (∼5 D), and can act as the metal chelator and C–H hydrogen bond donor interacting with electron-rich partners such as anions (Scheme 1).
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Scheme 1 The interactions of 1,2,3-triazole framework with metal ions and anions, (I),16 (II),9 (III),13,17 (1V).13 |
Several research groups have reported 1,4-disubstituted-1,2,3-triazoles as appropriate host for the complexation of different anions and have employed them in anion recognition where many weak C–H⋯Xn− interactions were accrued through hydrogen bonding and electrostatic interactions.10,11 Indeed, the large dipole moment of 1,2,3-triazoles and extrinsic polarization of a carbon atom in the 5-position afford hydrogen bonds involving C–H groups. Apart from anion complexation as hydrogen-bond-donor, the nitrogen-rich 1,2,3-triazols have the ability to coordinate a metal center as the N-donor ligands.8,18 Such characteristics introduce triazoles as important and powerful candidates in the catalysis field, particularly in metal-based catalysts. The 1,2,3-triazole as a high stable linker have attracted much attention for surface modifications and catalyst immobilization, and as the effective N-donor ligand can coordinate with metal ions and stabilize catalytic species on the surface of solid supports.19–21 Recently, these units have great tendency to coordination with many metal ions like Cu, Re, Pd, and etc.22,23
Polysaccharides have been widely applied as a suitable architecture for solid catalysts. Chitosan (CS), the N-deacetylated derivative of chitin, is a sample of such polysaccharides that is widely spread in living organisms. Due to the presence of reactive functional groups, free-amino groups and hydroxyl groups, CS and its composite-derivatives are considered to be proper solid supports for the immobilization of a metal catalyst. A main limiting problem in the consuming of CS in the catalysis fields is poor chemical resistance and mechanical strength, which significantly reduces the recycle life of the catalysts based on this biopolymer. Accordingly, it is often necessary to use stronger ligands or metal/metal oxide nanoparticles to modify fresh CS properties. Physical and chemical modifications improve pore size, mechanical strength, chemical stability, hydrophilicity and biocompatibility of the CS-based composites for catalytic applications. Several studies have been conducted toward developing chitosan coated magnetic nanoparticles. Miserez et al.24 prepared a composite of catechol-functionalized chitosan with superparamagnetic iron oxide (γ-Fe2O3) nanoparticles that represented a significant improvement in functionality of chitosan-based biomaterials. Zhao et al.25 reported a mesostructured Fe3O4/chitosan composite as a pH-responsive drug-delivery system. Movassagh et al.26 have reported magnetic porous chitosan-thienyl imine palladium(II) complex as an efficient and magnetically recoverable catalyst for the Mizoroki–Heck reaction.
Magnetic nanoparticles have been a topic of great interest in recent years, as their characteristics make them appropriate for use in various fields such as physics, medicine, biology, materials and catalysis science.27,28 The advantage of magnetic catalysts is the convenient separation and recovery from the reaction mixture using an external magnet. However, Fe3O4 nanoparticles have a tendency to aggregate because of strong magnetic dipole–dipole attractions between particles. Coating Fe3O4 nanoparticles with inorganic/organic polymers increases the stability of Fe3O4-based catalysts in reaction medium.
In continuation of our efforts towards the design of new and versatile catalysts employing the 1,2,3-triazole frameworks,17,29–31 in this work, the metal coordination ability of 1,2,3-triazole ring was used for surface modification and new catalyst design and the triazole-modified core–shell Fe3O4/chitosan was synthesized as a sustainable solid support for the immobilization of palladium catalyst. Herein, chitosan (CS) was used as an effective stabilizer agent for Fe3O4 nanoparticles (MNPs), in which polymer chains and Fe3O4 particles are connected to each other covalently via click reaction. The detailed route is shown in Scheme 2. This covalently-clicked connection increases the strength of the resulted solid support, and also the presence of nitrogen-rich triazole unites with excellent chelating ability to metal center could cause an increased capability of metal-immobilization for the support. The incorporation of palladium(II) complex into the click-Fe3O4/chitosan (click-MNPs/CS) gave the Pd@click-MNPs/CS, which could be successfully applied as a magnetic heterogonous, efficient, and green catalyst for the formylation of aromatic halides using formic acid as the CO-source in the presence of DCC activator.
The general term ‘carbonylation’ was expressed particularly for the various transformations that incorporate carbon monoxide into the organic compounds. Recently, carbonylation has become a powerful strategy for the preparation of carbonyl-containing organic combinations.32–34 To date, many researchers have focused their studies on the new CO gas-free carbonylation systems35–37 and reported the various carbonyl sources such as formic acid,38,39 Mo(CO)6,40 oxalic acid36 and N-formylsaccharin.41 Formic acid is an eco-friendly, cheap and available carbonyl source and can generate a carbon monoxide (CO) molecule in situ during the reaction process.42 The formic acid-assisted carbonylation catalyzed by palladium catalysts38,39 is an efficient approach for constructing carbonyl compounds. In another part of this work, the Pd@click-MNPs/CS was employed as a recyclable catalyst in the Suzuki–Miyaura cross-coupling of diverse aryl halides with phenylboronic acids in green solvent at room temperature. We also have studied the hydrogen bonding of triazole C–H by 1HNMR analysis of 1-benzyl-4-phenyl-1H-1,2,3-triazole in DMSO and CDCl3 solvents. In this part, the effects of the solvent and its polarity on the most stable structure of this compound and 1HNMR signal of triazole proton in the gas phase, DMSO and in CDCl3 solvent were theoretically investigated.
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Fig. 1 FTIR spectra of Fe3O4 nanoparticles (MNP) (a), pure chitosan (CS) (b), alkyne-functionalized chitosan (c), azide-functionalized Fe3O4 (d) and click-MNPs/CS (e). |
In the next step, the resulting azide-functionalized Fe3O4 particles were treated with alkynylated chitosan in the presence of Cu2O catalyst in mixed solvent H2O/DMF. During the “click” reaction, alkyne sections of alkynylated-CS react with azide groups grafted on the surface of Fe3O4 particles to obtain the 1,2,3-triazole functionalized-MNPs/CS. The cycloaddition reaction of alkyne and azide groups by the click process was confirmed using FTIR analysis, which revealed disappearance of the absorption bands at 2100 cm−1 and 2099 cm−1 attributed to the alkyne sections and N3, respectively (Fig. 1e). In addition, the IR absorption spectrum of click-MNPs/CS (Fig. 1d) reveals characteristic bands of both species, i.e., Fe3O4 particles43,44 and chitosan (CH, CO, CN, and OH stretching), confirming successful attachment of Fe3O4 nanoparticles with chitosan backbone.
In order to further study of the C5–H triazole interaction, the 1H NMR spectra of the 1-benzyl-4-phenyl-1H-1,2,3-triazole compound in the gas phase, in DMSO and in CDCl3 solvent have been investigated theoretically and the effect of the solvents on the most stable structure of the compound was evaluated. All the calculations have been carried out using Gaussian 09 Quantum Chemistry package.48 DFT methods employing Becke, 3-parameter, Lee–Yang–Parr (B3LYP) functional49 were used for the calculations. 6-311++G (2df, p) basis set was employed. The calculations in the presence of solvents have been done by the SMD method.50 At first, the structure of 1-benzyl-4-phenyl-1H-1,2,3-triazole compound was optimized in three different cases, in the gas phase, in DMSO and in CDCl3 solvent. As shown in Fig. 6, the selected dihedral angle (28N–29C–7C–8C) is 53.48, 57.23 and 72.88 in the gas phase, in the CDCl3 and in the DMSO solvent, respectively, which displays the influence of the solvent and its polarity on the optimized structure. The size of these dihedral angles may well confirm the existence of the interactions between DMSO and the triazole C–H proton (Fig. 7). Then, the 1H NMR spectra of the compound in three different cases have been calculated. The obtained results showed that the 1HNMR signal of triazole C–H proton was different in the different solvents with diverse polarity such as DMSO and CDCl3 and in the gas phase.
Entry | Solvent | Base | Catalyst [mol%] | DCC | Temp. (°C) | Yieldc [%] |
---|---|---|---|---|---|---|
a Reaction conditions:: 4-iodoanisole, HCOOH, DCC, catalyst, base, solvent (3 mL), 3 h.b Formic acid: 4 equiv.c Pure chitosan was used as catalyst.d Fe3O4/chitosan composite was used as catalyst. | ||||||
1 | H2O/EtOH (1![]() ![]() |
Na3PO4 (0.5 equiv.) | 0.3 | 2 equiv. | Reflux | 10 |
2 | PEG | Na3PO4 (0.5 equiv.) | 0.3 | 2 equiv. | 105 | 80 |
3 | PEG | Na3PO4 (0.5 equiv.) | 0.3 | 2 equiv. | 60 | 20 |
4 | PEG | Na3PO4 (1 equiv.) | 0.3 | 2 equiv. | 105 | 85 |
5 | PEG | K2CO3 (0.5 equiv.) | 0.3 | 2 equiv. | 105 | 80 |
6 | PEG | K2CO3 (0.5 equiv.) | 0.3 | — | 105 | 25 |
7 | PEG | K2CO3 (0.5 equiv.) | 0.3 | 1 equiv. | 105 | 50 |
8 | PEG | K2CO3 (0.5 equiv.) | 0.3 | 2 equiv. | 105 | 60b |
9 | PEG | K2CO3 (0.5 equiv.) | 0.1 | 2 equiv. | 105 | 10 |
10 | PEG | — | 0.3 | 2 equiv. | 105 | 60 |
11 | PEG | K2CO3 (0.5 equiv.) | — | 2 equiv. | 105 | — |
12 | PEG | DABCO (2 equiv.) | 0.3 | 2 equiv. | 105 | 85 |
13c | PEG | Na3PO4 (1 equiv.) | — | 2 equiv. | 105 | — |
14d | PEG | Na3PO4 (1 equiv.) | — | 2 equiv. | 105 | — |
In order to respect the principles of green chemistry, only eco-friendly solvents such as mixed EtOH/H2O (1:
1, v/v) and polyethylene glycol (PEG-200) were tested in experiments and PEG gave the best result. The concentration of base, formic acid and DCC was also surveyed in this reaction system and found to be important. Table 1 shows a summary of the optimization experiments, in which the optimized conditions were recognized as iodobenzene (1 equiv.), HCOOH (10 equiv.), DCC (2 equiv.), catalyst loading (0.3 mol%), Na3PO4 (1 equiv.) in PEG-200 at 105 °C (Table 1, entry 4). We then explored the scope and limitations of this transformation and several aryl halides were studied (Scheme 3). The aryl iodides and bromides were active in this reaction system and aryl boronic acids were found to be inactive. The electronic effects of aryl halides functionalized with various groups such as nitro, methoxy and methyl were also examined and it was found that aryl halides substituted with electron-donating groups compared to the electron-withdrawing substituents gave better yields. The methoxy- and methyl-aryl iodides afforded the corresponding aldehydes in excellent yields; however, low yield was observed using nitro-aryl iodides as the substrate. The Scheme 3 depicts a number of aldehydes synthesized by the Pd@click-MNPs/CS catalyst.
Compared with the previous works reported by other researchers on the pd-catalyzed carbonylation reactions, the most noteworthy advantages of our formylation methodology are eco-friendly, mild, phosphine-free conditions, reusability and low Pd-loading (0.3 mol%) of catalyst, good yields and short reaction times, while in the most previous reports, about 3-5 mol% of Pd catalysts combined with the phosphine ligands promote the reaction process.36,39,51–54 Most of the reported formic acid-assisted formylation reactions have been performed under homogeneous catalytic conditions; meanwhile, some researchers have recently directed their studies toward the use of heterogeneous Pd-catalysts for CO gas free formylation reactions.55,56
Based on our results and the other reports52,54 we have proposed a detailed mechanism for formic acid-assisted formylation reaction of aryl halides using Pd@click-MNPs/CS catalyst, in which the carbon monoxide molecule is formed in situ from the reaction of formic acid with DCC activator (Scheme 4). According to this mechanistic model, the free CO generated in the reaction media interacts with palladium-catalyst and forms an acyl-Pd intermediate in the catalytic cycle, next, followed by decarboxylation process and the reductive elimination reaction, the desired product is obtained. In this reaction system, the hydrogen source of the aldehyde products is considered to be formic acid and indeed, formic acid plays a dual role as both CO and hydrogen source to give the aldehyde groups.
The carbonyl group is one of the most common of the functional groups, and the carbonyl containing compounds are probably the most important class of organic molecules. Therefore, the construction of efficient catalytic systems for selective synthesis of these compounds will be noteworthy to follow in the near future.
Entry | Solvent | Base | Catalyst [mol%] | Yieldc [%] |
---|---|---|---|---|
a Reaction conditions: 4-iodoanisole (0.1 mmol), phenylboronic acid (0.12 mmol), H2O/EtOH (1![]() ![]() |
||||
1 | H2Ob | K2CO3 | 0.4 | 85 |
2 | H2O/EtOH (1![]() ![]() |
K2CO3 | 0.4 | 100 |
3 | H2O/EtOH (1![]() ![]() |
K2CO3 | 0 | — |
4 | H2O/EtOH (1![]() ![]() |
K2CO3 | 0.2 | 100 |
5 | H2O/EtOH (1![]() ![]() |
K2CO3 | 0.1 | 97 |
6 | H2O/EtOH (1![]() ![]() |
Na3PO4 | 0.2 | 100 |
7 | H2O/EtOH (1![]() ![]() |
KOH | 0.2 | 98 |
8d | H2O/EtOH (1![]() ![]() |
K2CO3 | — | — |
9e | H2O/EtOH (1![]() ![]() |
K2CO3 | — | — |
After optimization, we examined the reactivity of various types of aryl halides in this catalytic reaction system and it was found that the different biaryl derivatives were successfully synthesized by Pd@click-MNPs/CS catalyst using the Suzuki cross-coupling process (Table 3).
Entry | R (X) | T [°C] | t [h] | Yieldb [%] |
---|---|---|---|---|
a Reaction conditions: aryl halide (1 mmol), Phenylboronic acid (1.2 mmol), K2CO3 (2 mmol), solvent 3 mL.b GC yield. | ||||
1 | 4-OCH3 (I) | r.t. | 1 | 100 |
2 | 4-NO2 (I) | r.t. | 1 | 100 |
3 | 4-CH3 (I) | r.t. | 2 | 96 |
4 | 4-COCH3 (I) | r.t. | 2 | 100 |
5 | 3-NO2 (I) | r.t. | 1 | 100 |
6 | H (I) | r.t. | 1 | 95 |
7 | 4-COCH3 (Br) | r.t. | 2 | 95 |
8 | 3-COCH3 (Br) | 80 | 20 | 50 |
9 | 4-OCH3 (Br) | r.t. | 1 | 100 |
10 | 4-COH (Br) | r.t. | 2 | 95 |
11 | 4-CN (Br) | r.t. | 1 | 100 |
12 | 4-Cl (Br) | r.t. | 1 | 100 |
13 | 2-Cl (Br) | r.t. | 3 | 95 |
14 | 4-NO2 (Br) | r.t. | 20 | 25 |
15 | 4-NO2 (Br) | 70 | 1 | 95 |
16 | 2-NO2 (Br) | 70 | 20 | — |
17 | H (Cl) | r.t. | 3 | — |
18 | ![]() |
r.t. | 6 | 90 |
The electronic effects on the reaction times and yields were evaluated and electron-rich as well as electron-poor aryl iodides proceeded excellently to give the biaryl products. However, the reaction of nitro-aryl bromides afforded low yields at room temperature (Table 3 entry 14), while in contrast, methoxy-aryl bromide required shorter reaction times and gave brilliant yields (Table 3 entry 9). In the case of 4-nitrobromobenzene, when the reaction performed at room temperature, the corresponding coupled product was achieved in 25% of yield after 20 h, however, the yield of the product increased to 95% when the reaction was conducted at 70 °C for 1 h. Various functional groups such as cyano, methoxy, halogen, and carbonyl substituted on the aryl halides were compatible with this pd-catalyst system. Aryl chlorides were inactive in this system. The steric effects was evaluated and it was observed that an increasing hindrance in the vicinity of the leaving group using 2-bromonitrobenzene (Table 3, entry 16) led to a fall in the yield, however, the reaction by 2-bromochlorobenzene required long times, giving excellent conversion (Table 3, entry 13).
We also studied the efficiency of catalyst using 1,4-diiodobenzene as the substrate with various boronic acids (Scheme 5). It was found that the treatment of 1,4-diiodobenzene (1 equiv.) with phenylboronic acid (2 equiv.) in the presence of K2CO3 as the base (4 equiv.), H2O/EtOH (1:
1, v/v) as the solvent with catalyst loading 0.4 mol% at room temperature affords the coupled product 1,1':4′,1′′-terphenyl (b) in 75% yield after 2 h, however, under the same reaction conditions, the use of reaction temperature (80 °C) increases the yield of the corresponding coupled product up to 100%. Under these conditions, the reaction of 1,4-diiodobenzene substrate with naphthalene-1-boronic acid and naphthalene-2-boronic acid was also investigated. As shown in Scheme 5, both iodide groups in 1,4-diiodobenzene were completely reacted with naphthalene-1-boronic acid and the corresponding coupled product 1,4-di(naphthalen-1-yl)benzene (a) was formed in excellent yield. However, in the reaction of 1,4-diiodobenzene with naphthalene-2-boronic acid, the Suzuki product 2-(4-iodophenyl)naphthalene (c) was formed as the main product.
![]() | ||
Scheme 5 Reaction conditions: 1,4-diiodobenzene (1 equiv.), arylboronic acid (2.2 equiv.), catalyst (0.4 mol%), K2CO3 (4 equiv.), H2O/EtOH (1![]() ![]() |
We proposed a possible mechanism for the Suzuki–Miyaura coupling of 1,4-diiodobenzene with arylboronic acids using Pd@click-MNPs/CS as the catalyst, which is in consisted with previous reports.57 As shown in Scheme 6, a Pd(0)/Pd(II) catalytic cycle via an oxidative addition/reductive elimination mechanistic pathway has been reported, in which a complex Pd(II) intermediate undergoes reductive elimination to expel the coupled products.
The present catalyst system was compared with published reaction conditions reported by other groups for the Suzuki coupling of 4-bromoanisole with phenylboronic acid, and the results are summarized in Table 4. The present catalyst can be one of the best catalysts in terms of low reaction time, lower temperature, green media, easy separation and efficient recycling.
Entry | Catalyst Ref | Reaction conditions | Yield (%) |
---|---|---|---|
1 | Pd74Cu73 DENs58 | Catalyst (1 mol%), EtOH/H2O (3![]() ![]() |
99.7 |
2 | HEC-NHC-Pd59 | Catalyst (0.4 mol%), EtOH/H2O (3![]() ![]() |
84 |
3 | PET@IL/Pd60 | Catalyst (0.1 mol%), H2O, K2CO3, 55 °C, 45 min | 80 |
4 | MOP-BPY(Pd)61 | Catalyst (0.1 mol%), MeOH/H2O (1![]() ![]() |
91.3 |
5 | Present work | Catalyst (0.2 mol%), EtOH/H2O (1![]() ![]() |
100 |
The recyclability of heterogeneous catalyst is a key factor that is directly related to the catalyst stability and is a very essential topic from both the economic and environment points of view, especially for costly pd-based catalysts. Therefore, we carried out further investigations about the reusability and recovery of the Pd@click-MNPs/CS catalyst using the carbonylation and Suzuki cross-coupling reaction. After completing each reaction, the magnetic catalyst could be efficiently separate from the reaction media by an external magnet and reused for the next run. As demonstrated in Fig. 8, the catalyst could be recycled for at least four times without significant decrease in the catalytic activity.
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Fig. 8 The reusability results of the catalyst. Suzuki: 4-iodoanisole, carbonylation 4-iodotoluene as the substrates under the optimized conditions. |
The FT-IR spectra of the fresh and recovered catalyst from Suzuki reaction have been shown in Fig. 9. As can be seen, the recycled catalyst exhibited characteristic peaks of the chitosan (N–H, O–H, C–H, C–O) and Fe3O4 (Fe–O–Fe) similar to those of the fresh one, which indicate the stability of catalyst structures during the reaction process in aqueous media.
The fresh prepared Fe3O4 particles (1 g) were ultrasonically suspended in ethanol and then the solution of 3-azidopropyltrimethoxysilane in ethanol was added. The mixture was heated at 40 °C under nitrogen for 18 h. Then, the obtained azide-functionalized magnetic particles were magnetically separated and washed thoroughly with ethanol and dried under vacuum. The production of 3-azidopropyltrimethoxysilane and the successful grafting of azide groups on the magnetic particles surface were approved using FT-IR analysis.
Footnote |
† Electronic supplementary information (ESI) available. See DOI: 10.1039/d1ra03356e |
This journal is © The Royal Society of Chemistry 2021 |