Gui-Yuan Wu*a,
Chao Lianga,
Yi-Xiong Hub,
Xu-Qing Wangb,
Guang-Qiang Yinb and
Zhou Lu
*a
aAnhui Province Key Laboratory of Optoelectronic Material Science and Technology, School of Physics and Electronic Information, Anhui Normal University, Wuhu, Anhui 241002, China. E-mail: zhoulu@ahnu.edu.cn; wgy@ahnu.edu.cn
bShanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663 N. Zhongshan Road, Shanghai, China
First published on 4th January 2021
A discrete rhomboidal metallacycle R functionalized with bis-[2]pseudorotaxane of [Cu(phenanthroline)2]+ derivatives was successfully synthesized via coordination-driven self-assembly. Furthermore, the host–guest complexation of such a bis-[2]pseudorotaxane metallacycle with a bis-pillar[5]arene (bisP5) allowed for the formation of a new family of cross-linked supramolecular polymers R⊃(bisP5)2, which displayed interesting redox-responsive properties. By taking advantage of the substantial structural differences between the coordination geometries of [Cu(phenanthroline)2]+ and [Cu(phenanthroline)2]2+, the weight-average diffusion coefficients D of the supramolecular polymer were adjusted through changing the redox state of the Cu(I)/Cu(II) complexes.
Based on coordination-driven self-assembly, successful strategies have been developed for designing supramolecular polymers cross-linked by discrete metallacycles or metallacages. The combination of relatively rigid, discrete metal–organic scaffolds with elastic polymer networks allows for the construction of a new class of hybrid soft materials with stimuli-responsive properties. The discrete metallacycles or metallacages were used either as metallacycle skeletons or stimulus response sites in these supramolecular polymers as reported by various research groups.10–19 Such metallosupramolecular architectures are of particular interest not only for their fascinating structures but also because of their stimuli-sensitivities to a wide variety of environmental conditions including solvent composition, pH, temperature, light irradiation, and so on.20,21 However, the metallacycle-based redox-responsive supramolecular polymers are still rare.
One way to access such redox-responsive supramolecular materials is to utilize host–guest repeating units which contain one or more redox-active species, for example disulphide, selenium, ferrocene, tetrathiafulvalene, transition metal ions, and viologen counterparts.22–24 In particular, coordination complexes based on transition metals and bidentate polypyridine ligands, notably Cu(I)–phenanthroline complexes, typically present desirable redox properties for diverse applications such as molecular machines, catalysis, ultrafast spectroscopy, solar energy conversion, optoelectronics, and luminescence.25,26 Moreover, the Cu(I)–phenanthroline complexes feature some promising characteristics including the extra structural rigidity afforded by the phenanthroline unit, and the Cu(I)–phenanthroline complexes being oxidized to Cu(II)–phenanthroline complexes that undergoes significant and rapid Jahn–Teller (J–T) distortion from D2d to D2 symmetry.27–33 With this strategy, Sauvage and co-workers have successfully constructed topologically spectacular architectures such as pseudorotaxanes, rotaxanes, catenates and knots with Cu(I)–phenanthroline complexes. It is therefore possible to further utilize the Cu(I)–phenanthroline complexes as the basic building blocks to develop redox-responsive supramolecular polymers with the topology of [2]pseudorotaxane.
Using the HSA method, we previously reported a novel supramolecular polymer which was based on hexagonal metallacycle skeletons containing the above-mentioned Cu(I)–phenanthroline moiety. It was displayed that the redox-responsive of the resulting supramolecular polymers are strongly dependent on the oxidation state of copper. In order to further examine the versatility of this synthesis strategy and investigate the effects of metallacycle skeleton on the redox-responsive behaviours of the supramolecular polymers, we herein report another type of redox supramolecular polymer constructed by the well-defined rhomboidal bis-[2]pseudorotaxanes metallacycle through the hierarchical orthogonal design strategy based on coordination-driven self-assembly and host–guest interactions. First, the rhomboidal metallacycle R containing two [2]pseudorotaxane moieties was constructed by the coordination between 1,10-phenanthroline(phen) derivatives containing [2]pseudorotaxane and 60° di-Pt(II) acceptors, resulting in a rhomboidal metallacycle R of which the skeleton size is less than the previously reported hexagonal metallacycle M.34 Subsequently, hyperbranched supramolecular polymer was successfully constructed in the high-concentration region through host–guest interactions of rhomboidal metallacycle with the bis-pillar[5]arene (bisP5). Notably, the host–guest interactions were similar to covalent bond end-capping process and the Cu(I)N4 [2]pseudorotaxanes could act as the active sites which respond to the redox stimuli in supramolecular polymers. Supramolecular polymerization was shown to help the otherwise unstable tetrahedral complex Cu(II)N4 maintain enough stability during redox reactions. In addition, the tunability of the diffusion constants upon redox stimuli was also compared between the supramolecular polymers made of the R and M, showing the influence caused by the skeleton size.
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Scheme 1 Graphical representation of the self-assembled bis-[2]pseudorotaxanes rhomboidal metallacycle R. |
In the 1H NMR spectrum (Fig. 1 and S1†), the α- and β-pyridyl hydrogen signals both exhibited the obvious downfield shifts (Δδ ≈ 0.48 and 0.53 ppm for α-H; Δδ ≈ 0.47 and 0.54 ppm for β-H) because of the loss of electron density that occurred upon coordination of the pyridine-N atom with the Pt(II) metal center. Notably, two doublets were observed for both the α- and β-pyridine protons, which might be attributed to hindered rotation about the Pt–N(pyridyl) bond in a small cavity. The 31P NMR spectra of the metallacycle R displayed a sharp singlet (δ = 14.48 ppm), which shifted upfield from the signal of the starting platinum acceptor A by approximately 5.46 ppm (Fig. 1). This change, as well as the decrease in coupling of the flanking 195Pt satellites, is consistent with back-donation from the platinum atoms. Further characterization by 2-D 1H NMR spectroscopic techniques (1H–1H COSY and NOESY) were in agreement with the formation of the discrete bis-pseudorotaxanes metallacycles (Fig. S18†). For instance, the presence of cross-peaks between the signal of the pyridine protons (α-H and β-H) and the PEt3 protons (CH2 and CH3) were found in the 2-D NOESY spectrum, which supported the structure of metallacycle R as a result of the formation of N–Pt bonds (Fig. S18b†).
The structure of metallacycle R was also confirmed by ESI-TOF-MS, which allowed the assembly to remain intact to the maximum extent during the ionization process while retaining the high resolution required for resolving the isotopic distribution. For instance, the ESI-TOF-MS spectrum of R revealed three signals that corresponded to different charge states resulting from the loss of PF6− counterions, [R–3PF6]3+, [R–4PF6]4+, and [R–5PF6]5+, respectively, in which R represents the intact assembly (Fig. 2). Further investigation revealed that each isotope pattern of these signals was in good agreement with the corresponding simulation result. All evidence above supports the successful formation of discrete bis-[2]pseudorotaxanes rhomboidal metallacycle R by the donor D and accepter A via coordination-driven self-assembly (Scheme 1).
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Fig. 2 Theoretical (top) and experimental (bottom) ESI-TOF-MS spectra of bis-[2]pseudorotaxane rhomboidal metallacycles R. |
By making use of the recognition motif between the ditopic guest D and the host bisP5 along with their good solubility in acetone, the mixtures of tetratopic metallacycles R with the host bisP5 (1:
2 molar ratio of R and bisP5) at high concentration was expected to form a new family of cross-linked supramolecular polymers R⊃(bisP5)2. The concentration-dependent 1H NMR studies of complexes R⊃(bisP5)2 demonstrated the formation of such cross-linked supramolecular polymers. For instance, 1H NMR spectra (500 MHz, acetone-d6, 296 K) of the complex of R and bisP5 in a 1
:
2 molar ratio over a range of metallacycle R unit concentrations from 0.1 up to 3.0 mM were recorded with the purpose of probing the process of the supramolecular polymer formation (Fig. 3a). At low concentration (<0.5 mM), no obvious signal broadening was found, indicating that poly[3]pseudorotaxanes predominated in solution at low concentration. Upon increasing the concentrations, the signal of H5, H8 and H9 gradually became unobvious and finally disappeared. In the meanwhile, the Hm′ peak became broadened markedly at higher concentrations. These observations gave clean evidence for the formation of cross-linked supramolecular polymers through host–guest interactions (Fig. S4†) in the high concentration region.54
Two-dimensional diffusion-ordered 1H NMR spectroscopy (DOSY) experiments were performed to provide further evidence for the formation of cross-linked supramolecular polymers. From Fig. 3b, the measured weight average diffusion coefficient (D) of R⊃(bisP5)2 decreased remarkably from 3.55 × 10−9 to 0.2 × 10−9 m2 s−1 (D 1.0 mM/D 12.0 mM = 17.8) as the concentration of R⊃(bisP5)2 increased from 1.0 to 12.0 mM. In general, a more than 10-fold decrease of the diffusion coefficient is believed to be the important evidence for the formation of a polymerization with high degree.41 Therefore, the results from Fig. 3b clearly indicates that the initially small poly[3]pseudorotaxanes grew into larger across-linked supramolecular polymers with the increase in R⊃(bisP5)2 concentration. These DOSY experimental results also further revealed that the generation of such supramolecular polymers was concentration dependent. Importantly, a higher diffusion coefficient (D) of the generated supramolecular aggregates were observed for R⊃(bisP5)2 when comparing with the previously reported M⊃(bisP5)3 at the same concentration of [Cu(phenanthroline)2]+ unit. For example, the D values of R⊃(bisP5)2 and M⊃(bisP5)3 were 1.26 × 10−9 m2 s−1 and 0.35 × 10−9 m2 s−1, respectively, when the concentration of [Cu(phenanthroline)2]+ unit was 6 mM in acetone (Fig. S5†). Such a difference in the diffusion constants indicates that the rhomboidal metallacycle R probably yielded in smaller supramolecular polymers than the hexagonal metallacycle M, therefore proving that the skeleton of the metallacycle has a significant effect on supramolecular polymers size.
In order to further demonstrate the role of bisP5 as the “cross-linking agent” in the formation of such supramolecular polymers. The scanning electron microscopy (SEM) studies were performed, which provided the direct evidence for the existence of supramolecular polymerization of R⊃(bisP5)2 and further insight into the morphological characteristics of cross-linked supramolecular polymers. As shown in Fig. S6,† the typical spherical morphologies for metallacycle R in acetone solvents were observed at low concentration (≤1.0 mM). With the increasing of concentrations, the formation of cube morphologies and the increase of spherical radius for metallacycle R in acetone solvents were observed, indicating the predominance of the oligomers when the concentration of metallacycle R is more than 1 mM. On the other hand, the more irregular and extended three-dimensional (3-D) networks for R⊃(bisP5)2 systems were observed with the presence of bisP5, which was consistent with the typical morphology of cross-linked supramolecular polymers (Fig. 3c and S7†).
In current work, the redox-responded behaviors of supramolecular polymers R⊃(bisP5)2 were also examined. Likewise, 1H NMR, 31P NMR, UV-vis, DOSY and SEM experiments showed that the supramolecular polymer R⊃(bisP5)2 were almost unbroken upon the redox stimulation. In the partial 1H NMR measurements, signals from the protons Hm and Hm′ on the phenanthroline moiety almost disappeared when Cu(I) was oxidized into Cu(II) by NOBF4. Interestingly, the proton peaks of R⊃(bisP5)2 were almost completely restored when the Cu(II) was reduced to Cu(I) by ascorbic acid(ASA) (Fig. 4a and S8†), showing the reversibility of redox manipulations on R⊃(bisP5)2. More importantly, the signal of the proton H9 remained absent during the redox process, indicating that the bisP5 exhibited very strong binding affinities towards the dinitriles guest which resulted in the stable cross-linked supramolecular polymers. 31P NMR and SEM of supramolecular polymers also showed negligible changes during the redox-responded processes (Fig. 4b and S9†). These results demonstrate that the formation of stable supramolecular polymers with rhomboidal metallacycle scaffolds in the extended network through host–guest interactions and degrees of such cross-linked polymerization remain unchanged during the redox reactions.
To verify the actual occurrence of the redox reactions, the UV-vis spectroscopic measurements on reduced and oxidized R⊃(bisP5)2 in acetone (0.1 mM) were carried out (Fig. 4c). A metal-to-ligand charge-transfer (MLCT) absorption band at 437 nm was observed in UV-vis absorption spectra for the original R⊃(bisP5)2 solution, indicated that the entwined arrangement of both phen units around Cu(I). When R⊃(bisP5)2 was oxidized by addition of NOBF4, the color of the solution changed from red-brown to emerald-green, while a new d–d absorption band appeared at 667 nm and the absorption peak at 550 nm became weaker. The addition of ascorbic acid triggered the reversed process: the color of solution turned back to red-brown and the resultant UV-vis absorption spectrum again became identical to that of the complex Cu(I)N4 (Fig. 4c).
The 2-D DOSY NMR experiment on R⊃(bisP5)2 was performed as well during the oxidation and reduction processes. As can be observed in Fig. 4d, the final weight-average diffusion coefficients D increased to 1.32 × 10−9 during the process of oxidation in R⊃(bisP5)2 ([Cu(phenanthroline)2]+ unit = 9 mM) (DCu(II)/DCu(I) = 2.54) (Fig. 4d and S10†). We have previously reported that the oxidation of M⊃(bisP5)3 ([Cu(phenanthroline)2]+ unit = 9 mM) resulted in a more dramatic increase of the measured weight-average diffusion coefficients D from 0.3 × 10−9 to 1.55 × 10−9 m2 s−1 (DCu(II)/DCu(I) = 4.70). These observations clearly demonstrated that the larger frame size of metallacycle has greater influence on the size changes of supramolecular polymer after oxidation (Table S1†). Moreover, the weight-average diffusion coefficient D of R⊃(bisP5)2 decreased to 0.62 × 10−9 when 8.0 equiv. ASA was added to the Cu(II)N4 on the R⊃(bisP5)2. Further analysis indicated that the above phenomena mainly resulted from the fact that the Cu(I)N4 complexes with the distorted tetrahedral geometry of approximate C2 symmetry were transformed into Cu(II)N4 with the D2 symmetry structures and the symmetry of the D2 structures was higher than that of the C2 symmetry structures. The change of metal complexes from the more asymmetric ones to highly symmetric structures drove a loose supramolecular polymer structure to form a more compact network, which might caused an increase in diffusion coefficients (Scheme 2).
Footnote |
† Electronic supplementary information (ESI) available: Materials, measurements, synthesis and characterization data, UV-vis spectra. See DOI: 10.1039/d0ra09920a |
This journal is © The Royal Society of Chemistry 2021 |