Issue 23, 2021

Alternative mechanism of action of the DNP PtIV prodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway

Abstract

In a recent research paper Dr. Suxing Jin et al. reported two multispecific PtIV complexes DNP and NP with non-steroidal anti-inflammatory drug naproxen (NPX) as the axial ligand(s). Herein, we clarify the mechanism of action of DNP, its therapeutic target and intracellular redox-status.

Graphical abstract: Alternative mechanism of action of the DNP PtIV prodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway

Supplementary files

Article information

Article type
Communication
Submitted
18 Mar 2021
Accepted
17 Apr 2021
First published
20 Apr 2021

Dalton Trans., 2021,50, 7922-7927

Alternative mechanism of action of the DNP PtIV prodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway

O. Krasnovskaya, D. Spector, A. Erofeev, P. Gorelkin, R. Akasov, D. Skvortsov, A. Trigub, K. Vlasova, A. Semkina, N. Zyk, E. Beloglazkina and A. Majouga, Dalton Trans., 2021, 50, 7922 DOI: 10.1039/D1DT00898F

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