Open Access Article
This Open Access Article is licensed under a
Creative Commons Attribution 3.0 Unported Licence

Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates

Stephen J. Walsh a, Soleilmane Omarjee b, Warren R. J. D. Galloway a, Terence T.-L. Kwan a, Hannah F. Sore a, Jeremy S. Parker c, Marko Hyvönen d, Jason S. Carroll *b and David R. Spring *a
aDepartment of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. E-mail: spring@ch.cam.ac.uk
bCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, CB2 0RE, UK. E-mail: jason.carroll@cruk.cam.ac.uk
cEarly Chemical Development, Pharmaceutical Development, IMED Biotech Unit, AstraZeneca, Macclesfield, UK
dDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK

Received 28th November 2018 , Accepted 28th November 2018

First published on 13th December 2018


Correction for ‘A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates’ by Stephen J. Walsh et al., Chem. Sci., 2019, DOI: 10.1039/c8sc04645j.


The authors regret that Fig. 1 is incorrect in the original manuscript. Structures, ticks and crosses were absent. The correct figure is displayed below.
image file: c8sc90248h-f1.tif
Fig. 1 (a) Previous work using monovinylpyridine or maleimide linkers for the generation of ADCs from native antibodies and (b) the divinylpyrimidine (DVP) linkers developed in this work generate homogeneous and stable ADCs via cysteine re-bridging (crosslinking).

The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


This journal is © The Royal Society of Chemistry 2019