You-Ping Tian, Yi Gong, Xiao-Si Hu, Jin-Sheng Yu, Ying Zhou and Jian Zhou
Org. Biomol. Chem., 2019,17, 9430-9434
DOI:
10.1039/C9OB02129A,
Communication
A highly efficient metal-free aldol-type reaction of various acetals or ketals with fluorinated silyl enol ethers catalysed by less than 1 mol% HClO4 (70 wt%, aq.) is developed. This provides expedient access to a wide array of valuable fluoroalkyl ethers featuring a ketone carbonyl functionality in good to excellent yields (40 examples). Furthermore, the thus obtained adducts are readily elaborated into other fluorine-containing alkyl ethers with a rich structure.