Meng Zheng, Martin Mex, Kathrin H. Götz and Andreas Marx
Org. Biomol. Chem., 2018,16, 8904-8907
DOI:
10.1039/C8OB01894D,
Communication
Poly(ADP-ribose) polymerase-1 (PARP-1) is an important target in cancer therapy. We present the synthesis of novel disaccharide nucleoside analogues that resemble the central motif of poly(ADP-ribose) and test their inhibitory effects on human PARP-1. Some compounds show inhibition of enzymatic activity in vitro and thus might be interesting for further investigations.
