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Correction: Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies
Sachin S.
Shivatare
a,
Lin-Ya
Huang
a,
Yi-Fang
Zeng
a,
Jung-Yu
Liao
a,
Tsai-Hong
You
a,
Shi-Yun
Wang
a,
Ting
Cheng
b,
Chih-Wei
Chiu
a,
Ping
Chao
a,
Li-Tzu
Chen
a,
Tsung-I
Tsai
c,
Chiu-Chen
Huang
a,
Chung-Yi
Wu
*b,
Nan-Horng
Lin
*a and
Chi-Huey
Wong
*bc
aCHO Pharma Inc., 18F, Building F, No. 3, Park Street, Nangang District, Taipei-11503, Taiwan. E-mail: nhlin@chopharma.com.tw
bGenomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang District, Taipei 115, Taiwan. E-mail: cyiwu@gate.sinica.edu.tw; chwong@gate.sinica.edu.tw
cDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
First published on 2nd July 2018
Abstract
Correction for ‘Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies’ by Sachin S. Shivatare et al., Chem. Commun., 2018, 54, 6161–6164.
The authors regret that there was an error in Fig. 3 in the original manuscript. The value for the FcγIIIA binding of Rtx-G16 in Fig. 3 was given as 5.4 but should be 33. The corrected version of Fig. 3 is presented below. There was also an error in the original caption. The last sentence in the caption referred to “maximal FcγIIA binding”. This should have read “maximal FcγIIIA binding”.
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| Fig. 3 Rtx-variants generated via Fc-glycosylation using Rtx-N as an acceptor and various glycan oxazolines as donors. (a) EndoS2 mutant required. (b) Binding between FcγRIIIA and Rtx-variants. Fold of enhancement of EC50 compared to commercial Rtx. (c) ADCC activities of selected Rtx-variants. Fold of enhancement of EC50 compared to commercial Rtx. EC50 in ng mL−1 refers to the concentration of an antibody that gives 50% of the maximal FcγIIIA binding or maximal cell killing. | ||
The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
| This journal is © The Royal Society of Chemistry 2018 |