Issue 59, 2018
From the journal:

Chemical Communications

Supramolecular chemotherapeutic drug constructed from pillararene-based supramolecular amphiphile†

Dan Wu, ORCID logo ‡a   Yang Li,‡a   Jie Shen,*b   Zaizai Tong, ORCID logo c   Qinglian Hu,d   Liping Lie  and  Guocan Yu ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China
E-mail: guocanyu@zju.edu.cn

b School of Medicine, Zhejiang University City College, Hangzhou 310015, P. R. China
E-mail: shenj@zucc.edu.cn

c Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education, Department of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, P. R. China

d College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China

e Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

Abstract

Based on the host–guest interaction between a CPT-conjugated prodrug amphiphile (CPT-ss-Py) and a water-soluble pillar[5]arene (P5), a GSH-responsive supramolecular chemotherapeutic drug (P5⊃CPT-ss-Py) was fabricated. Through this supramolecular formulation, internalization and anticancer efficacy were greatly increased.

Graphical abstract: Supramolecular chemotherapeutic drug constructed from pillararene-based supramolecular amphiphile

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Article information

DOI
https://doi.org/10.1039/C8CC04334E
Article type
Communication
Submitted
31 May 2018
Accepted
21 Jun 2018
First published
22 Jun 2018

Chem. Commun., 2018,54, 8198-8201

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Supramolecular chemotherapeutic drug constructed from pillararene-based supramolecular amphiphile

D. Wu, Y. Li, J. Shen, Z. Tong, Q. Hu, L. Li and G. Yu, Chem. Commun., 2018, 54, 8198 DOI: 10.1039/C8CC04334E

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