Issue 59, 2018

Copper-catalyzed cyclization of 2-cyanobenzaldehydes and 2-isocyanoacetates: an efficient strategy for the synthesis of substituted 1-aminoisoquinolines

Abstract

A Cu(acac)2-catalyzed cyclization reaction of 2-cyanobenzaldehydes with 2-isocyanoacetates has been successfully developed providing an efficient strategy for the synthesis of substituted 1-aminoisoquinolines. The reaction proceeds smoothly under mild conditions with high efficiency, and might provide an alternative strategy for the synthesis of 1-aminoisoquinoline containing molecules.

Graphical abstract: Copper-catalyzed cyclization of 2-cyanobenzaldehydes and 2-isocyanoacetates: an efficient strategy for the synthesis of substituted 1-aminoisoquinolines

Supplementary files

Article information

Article type
Communication
Submitted
13 Jun 2018
Accepted
28 Jun 2018
First published
29 Jun 2018

Chem. Commun., 2018,54, 8194-8197

Copper-catalyzed cyclization of 2-cyanobenzaldehydes and 2-isocyanoacetates: an efficient strategy for the synthesis of substituted 1-aminoisoquinolines

W. Bao, J. Wang, X. Xu, B. Zhang, W. Liu, L. Lei, H. Liang, K. Zhang and S. Wang, Chem. Commun., 2018, 54, 8194 DOI: 10.1039/C8CC04733B

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