Issue 34, 2018

1,3-Iodo-amination of 2-methyl indoles via Csp2–Csp3 dual functionalization with iodine reagent

Abstract

A 1,3-iodo-amination with iodine reagent that involved the Csp2–Csp3 dual functionalization of 2-methyl indoles was developed to provide 2-aminomethyl-3-iodo-indole derivatives. The iodo-amination proceeded via a 1,4-transfer of an imide group through the formation of an indolyl(phenyl)iodonium imide using PhI(OAc)2, followed by an iodination using DIH or a double iodination of indole using excess DIH.

Graphical abstract: 1,3-Iodo-amination of 2-methyl indoles via Csp2–Csp3 dual functionalization with iodine reagent

Supplementary files

Article information

Article type
Communication
Submitted
15 Jan 2018
Accepted
09 Feb 2018
First published
09 Feb 2018

Chem. Commun., 2018,54, 4258-4261

1,3-Iodo-amination of 2-methyl indoles via Csp2–Csp3 dual functionalization with iodine reagent

K. Moriyama, T. Hamada, K. Ishida and H. Togo, Chem. Commun., 2018, 54, 4258 DOI: 10.1039/C8CC00352A

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